PolySearch2 - Given Bisphenol A, Find


ZScore RScore Entity ID Name Synonyms Hits
13.80 140 DID06582 breast neoplasm breast neoplasm; Breast tumour; Neoplasm of breast; Breast Neoplasm; Tumors, Breast; Breast Tumor; Tumor of the Breast; Tumor, Breast; mammary tumor; Breast Neoplasms; Tumor of breast; Tumour of breas... (Read More) 16 [0, 0, 3, 13]
13.23 135 DID38503 Diabetes mellitus Diabetes mellitus; DM - Diabetes mellitus; diabetes; Diabetes mellitus (disorder); Diabetes nos... (Read More) 11 [0, 0, 4, 7]
11.53 120 DID71361 Obesity Obesity... (Read More) 7 [0, 1, 2, 4]
4.72 60 DID70477 Disease Disease... (Read More) 8 [0, 0, 1, 7]
3.02 45 DID44631 infertility infertility; Infertile; Difficulty conceiving... (Read More) 5 [0, 0, 1, 4]
3.02 45 DID40143 Autistic thinking Autistic thinking; Autism... (Read More) 5 [0, 0, 1, 4]
2.45 40 DID49494 Generalized metabolic disorder Generalized metabolic disorder; METABOLIC DISORDERS; Diseases, Metabolic; Metabolic disease; Thesaurismosis; Metabolic disorder; Thesaurismoses; Metabolic Diseases; metabolism disorder; Disease, Metab... (Read More) 4 [0, 0, 1, 3]
2.45 40 DID06067 Fibroid Fibroid; Fibromyoma; Leiomyomatous Neoplasm; Leiomyoma; Fibromyomas; Leiomyomatous neoplasms; Fibroids; Fibroid Tumors; Fibroid Tumor; fibroid; Leiomyomas; Leiomyomatous Tumor; Leiomyoma nos (morpholo... (Read More) 4 [0, 0, 1, 3]
1.88 35 DID66820 Sudek's Atrophy Sudek's Atrophy; Shoulder-hand syndrome; Reflex sympathetic dystrophy; Sudek's atrophy; Complex Regional Pain Syndrome, Type I; Sudeck's atrophy; RSD - Reflex sympathetic dystrophy; Complex regional p... (Read More) 7 [0, 0, 0, 7]
1.88 35 DID06289 Ovarian Carcinoma Ovarian Carcinoma; Ovarian Cancers; CARCINOMA OF OVARY; Ovary Cancer; Cancer of the Ovary; Cancer of Ovary; Ovarian Cancer; Ovary Cancers; OVARIAN CARCINOMA; Cancer, Ovarian... (Read More) 3 [0, 0, 1, 2]
1.88 35 DID47685 Allergy Allergy; Hypersensitivity reaction type i disease; Hypersensitivity... (Read More) 3 [0, 0, 1, 2]
1.32 30 DID40352 tumorigenesis tumorigenesis; oncogenesis; Tumorigenesis... (Read More) 2 [0, 0, 1, 1]
1.32 30 DID59006 genotoxicity genotoxicity... (Read More) 2 [0, 0, 1, 1]
1.32 30 DID07248 Osteosarcoma Osteosarcoma; Mouse Osteosarcoma... (Read More) 2 [0, 0, 1, 1]
1.32 30 DID06945 LIVER FATTY CHANGE LIVER FATTY CHANGE; Liver Steatosis; hepatic steatosis; Steatosis of liver; Hepatic lipidosis; STEATOSIS HEPATIC; LIVER FATTY; Liver, Fatty; LIVER FATTY DEGENERATION; Fatty change of liver; Fatty live... (Read More) 2 [0, 0, 1, 1]
1.32 30 DID31595 Diabetes Mellitus, Type II Diabetes Mellitus, Type II; MODY; DIABETES, MATURITY ONSET; Diabetes Mellitus, Non Insulin Dependent; NIDDM - Non-insulin dependent diabetes mellitus; Diabetes Mellitus, Type 2; AODM; Type 2 diabetes ... (Read More) 2 [0, 0, 1, 1]
1.32 30 DID32555 Atopic neurodermatitis Atopic neurodermatitis; Atopic Dermatitis; Disseminated neurodermatitis; Besnier's prurigo; ECZEMA, ATOPIC; Atopic Eczema; AD - Atopic dermatitis; DERMATITIS ALLERGIC; Allergic eczema; Allergic dermat... (Read More) 2 [0, 0, 1, 1]
1.32 30 DID44658 Asthma Asthma... (Read More) 2 [0, 0, 1, 1]
1.32 30 DID44887 Abnormal hepatic function Abnormal hepatic function; Hepatic dysfunction; Liver Dysfunction; Abnormal liver function; Liver Dysfunctions; Dysfunction, Liver... (Read More) 2 [0, 0, 1, 1]

Associated Diseases - DID06582 : breast neoplasm

ZScoreRScoreEntity TypeIDNameSynonyms
13.7966588225 140 - [0, 0, 3, 13] Diseases DID06582 breast neoplasm breast neoplasm; Breast tumour; Neoplasm of breast; Breast Neoplasm; Tumors, Breast; Breast Tumor; Tumor of the Breast; Tumor, Breast; mammary tumor; Breast Neoplasms; Tumor of breast; Tumour of breast; Neoplasm of the Breast; Mammary Neoplasms; Breast Tumors; NEOPLASM BREAST; Neoplasm, Breast; Breast cancer; Breast cancer; Ca breast - nos; Malignant neoplasm of breast; Malignant tumor of the breast; Mammary cancer; Primary breast cancer

Evidence Section : DID06582 - MEDLINE

RScore Document Snippets
45 - [0, 0, 1, 4] Urban Endocrine Disruptors Targeting Breast Cancer Proteins.
[MEDLINE : 26700111]
(2016) Urban Endocrine Disruptors Targeting Breast Cancer Proteins. Chemical research in toxicology;Chem. Res. Toxicol.;2016 Feb;29(2):150-61

- Urban Endocrine Disruptors Targeting Breast Cancer Proteins.

- Some of the chemicals that exhibited the best affinity scores for breast cancer proteins in each category were 1,3,7,8-tetrachlorodibenzo-p-dioxin, bisphenol A derivatives, perfluorooctanesulfonic acid, and benzo (a) pyrene, for catalase, several proteins, sex hormone-binding globulin, and cytochrome P450 1A2, respectively.

- Many of these compounds have been associated with a broad range of diseases including the development or increased susceptibility to breast cancer, the most prevalent cancer in women worldwide, according to the World Health Organization.

- Thus, this article presents a virtual high-throughput screening (vHTS) to evaluate the affinity of proteins related to breast cancer, such as ESR1, ERBB2, PGR, BCRA1, and SHBG, among others, with EDCs from urban sources.

- In short, this work shows the potential of several EDCs to bind breast cancer associated proteins as a tool to prioritize compounds to perform in vitro analysis to benefit the regulation or exposure prevention by the general population.

30 - [0, 0, 1, 1] Editor's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells.
[MEDLINE : 28591870]
(2017) Editor's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells. Toxicological sciences : an official journal of the Society of Toxicology;Toxicol. Sci.;2017 08;158(2):431-443

- These findings point to the importance of better understanding the risk of adverse effects from exposure to BPA alternatives, including hormone-dependent breast cancer.

- Editor 's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells.

25 - [0, 0, 0, 5] Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7.
[MEDLINE : 30616060]
(2019) Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7. Environmental pollution (Barking, Essex : 1987);Environ. Pollut.;2019 Mar;246:697-703

- These results illustrated that BPS exposure might play roles in the progression of breast cancer.

- Besides, methylation status in promoter of breast cancer related genes CDH1, SFN, TNFRSF10C were also changed, which implied that BPS might play a role in the development of breast cancer.

- Gene expression profiling showed that some genes related to breast cancer progression were upregulated, including THBS4, PPARGC1A, CREB5, COL5A3.

- Gene ontology (GO) analysis of the differentially expressed genes revealed the significantly changes in PI3K-Akt signaling pathway and extracellular matrix, which were related to the proliferation, migration and invasion of breast cancer cells.

- Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7.

25 - [0, 0, 1, 0] DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients.
[MEDLINE : 28505145]
(2017) DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients. Genes;Genes (Basel);2017 May;8(5):

- DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients.

5 - [0, 0, 0, 1] Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells.
[MEDLINE : 29093337]
(2017) Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells. Biological & pharmaceutical bulletin;Biol. Pharm. Bull.;2017 ;40(11):1909-1916

- Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells.

5 - [0, 0, 0, 1] Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk.
[MEDLINE : 26911702]
(2016) Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk. Hormones & cancer;Horm Cancer;2016 08;7(4):241-51

- The recent rise in incidence of human breast cancer and decreased age of first detection suggests a possible environmental etiology.

5 - [0, 0, 0, 1] Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors.
[MEDLINE : 26704594]
(2016) Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors. Journal of medicinal chemistry;J. Med. Chem.;2016 Jan;59(1):157-70

- The hypothesis is that in normal tissue the estrogenic SERM activity of a dual AI/SERM could attenuate the undesired effects stemming from global estrogen depletion caused by the AI activity of a dual AI/SERM, while in breast cancer tissue the antiestrogenic SERM activity of a dual AI/SERM could act synergistically with AI activity to enhance the antiproliferative effect.


Associated Diseases - DID38503 : Diabetes mellitus

ZScoreRScoreEntity TypeIDNameSynonyms
13.2294048917 135 - [0, 0, 4, 7] Diseases DID38503 Diabetes mellitus Diabetes mellitus; DM - Diabetes mellitus; diabetes; Diabetes mellitus (disorder); Diabetes nos

Evidence Section : DID38503 - MEDLINE

RScore Document Snippets
55 - [0, 0, 2, 1] Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?
[MEDLINE : 30359670]
(2018) Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?. Life sciences;Life Sci;2018 Dec;214:136-144

- As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adipocyte and skeletal muscles.

- Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes.

- Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

25 - [0, 0, 1, 0] Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes.
[MEDLINE : 31004310]
(2019) Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes. Molecular and cellular biochemistry;Mol. Cell. Biochem.;2019 Aug;458(1-2):171-183

- Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes.

25 - [0, 0, 1, 0] Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes. A Pilot Study.
[MEDLINE : 28095285]
(2016) Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes. A Pilot Study. Central European journal of public health;Cent. Eur. J. Public Health;2016 12;24(4):297-301

- Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes.

15 - [0, 0, 0, 3] Lipophilic chemical exposure as a cause of type 2 diabetes (T2D).
[MEDLINE : 23509204]
(2013) Lipophilic chemical exposure as a cause of type 2 diabetes (T2D). Reviews on environmental health;Rev Environ Health;2013 ;28(1):9-20

- Recent research has shown that diabetes can be caused by exposure to persistent organic pollutants (POPs), exudates from common plastics, air pollution, primary and secondary tobacco smoke, and some pharmaceuticals.

- Lipophilic chemical exposure as a cause of type 2 diabetes (T2D).

- The prevalence of type 2 diabetes (T2D) is increasing worldwide in pandemic-like numbers.

5 - [0, 0, 0, 1] Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice.
[MEDLINE : 28962342]
(2015) Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice. Toxicology reports;Toxicol Rep;2015 ;2:99-110

- Previous observations that BPA exposure increased the prevalence of diabetes and insulitis and decreased the number of tissue resident macrophages in pancreas were confirmed, and extended by demonstrating that BPA exposure also impaired the phagocytic activity of peritoneal macrophages.

5 - [0, 0, 0, 1] The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins.
[MEDLINE : 26164745]
(2015) The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins. Environmental toxicology and pharmacology;Environ. Toxicol. Pharmacol.;2015 Jul;40(1):284-91

- The alteration of nutritional intake and fat metabolism may affect the maintenance of pregnancy and supplementation of nutrients to the fetus, and therefore can cause severe metabolic diseases such as ketosis, marasmus and diabetes mellitus in pregnant individuals.

5 - [0, 0, 0, 1] Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice.
[MEDLINE : 24959901]
(2014) Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice. PloS one;PLoS ONE;2014 ;9(6):e100214

- This term refers to a form of diabetes which typically develops in later life and is associated with obesity.


Associated Diseases - DID71361 : Obesity

ZScoreRScoreEntity TypeIDNameSynonyms
11.5276430993 120 - [0, 1, 2, 4] Diseases DID71361 Obesity Obesity

Evidence Section : DID71361 - MEDLINE

RScore Document Snippets
55 - [0, 1, 0, 1] Obesity aggravates toxic effect of BPA on spermatogenesis.
[MEDLINE : 28501790]
(2017) Obesity aggravates toxic effect of BPA on spermatogenesis. Environment international;Environ Int;2017 08;105:56-65

- Obesity aggravates toxic effect of BPA on spermatogenesis.

- Both bisphenol A (BPA) and obesity affect male reproductive system.

25 - [0, 0, 1, 0] Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?
[MEDLINE : 30359670]
(2018) Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?. Life sciences;Life Sci;2018 Dec;214:136-144

- Obesity, hepatic steatosis, impaired insulin signaling and pancreatic islet function could be the main results of Bisphenol A exposure.

25 - [0, 0, 1, 0] Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health.
[MEDLINE : 29223775]
(2018) Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health. Environmental research;Environ. Res.;2018 02;161:505-511

- Both bisphenol A and phthalates have been suggested as playing a role in obesity epidemics.

5 - [0, 0, 0, 1] Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver.
[MEDLINE : 31683443]
(2020) Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver. Chemosphere;Chemosphere;2020 Feb;241:125092

- Environmental pollution is increasingly considered an important factor involved in the obesity incidence.

5 - [0, 0, 0, 1] Short and long-term effects of bisphenol S (BPS) exposure during pregnancy and lactation on plasma lipids, hormones, and behavior in rats.
[MEDLINE : 31003143]
(2019) Short and long-term effects of bisphenol S (BPS) exposure during pregnancy and lactation on plasma lipids, hormones, and behavior in rats. Environmental pollution (Barking, Essex : 1987);Environ. Pollut.;2019 Jul;250:312-322

- Furthermore, the increased preference for the fat-enriched diet suggests an increased risk for obesity and its health consequences in the long term.

5 - [0, 0, 0, 1] Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice.
[MEDLINE : 24959901]
(2014) Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice. PloS one;PLoS ONE;2014 ;9(6):e100214

- This term refers to a form of diabetes which typically develops in later life and is associated with obesity.


Associated Diseases - DID70477 : Disease

ZScoreRScoreEntity TypeIDNameSynonyms
4.72059592982 60 - [0, 0, 1, 7] Diseases DID70477 Disease Disease

Evidence Section : DID70477 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease.
[MEDLINE : 32796699]
(2020) Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease. International journal of molecular sciences;;2020 Aug;21(16):

- Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease.

10 - [0, 0, 0, 2] Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A.
[MEDLINE : 27334623]
(2016) Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A. Environmental and molecular mutagenesis;Environ. Mol. Mutagen.;2016 07;57(6):435-46

- This work demonstrated that epigenome-wide discovery experiments in animal models were effective tools for identification and understanding of paralagous epimutations salient to human disease.

- These tumors represent early-onset disease and lack classical sexual dimorphism in incidence.

5 - [0, 0, 0, 1] Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver.
[MEDLINE : 31683443]
(2020) Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver. Chemosphere;Chemosphere;2020 Feb;241:125092

- Endocrine disruptors (EDs) are important actors in the concept of DOHaD (Developmental Origins of Health and Disease), where epigenetic mechanisms play crucial roles.

5 - [0, 0, 0, 1] Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism.
[MEDLINE : 28567415]
(2017) Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism. International journal of genomics;Int J Genomics;2017 ;2017:7526592

- The Developmental Origin of Health and Disease (DOHaD) hypothesizes that the environment during fetal and childhood development affects the risk for many chronic diseases in later stages of life, including neurodevelopmental disorders.

5 - [0, 0, 0, 1] Long Non-Coding RNAs: A Novel Paradigm for Toxicology.
[MEDLINE : 27864543]
(2017) Long Non-Coding RNAs: A Novel Paradigm for Toxicology. Toxicological sciences : an official journal of the Society of Toxicology;Toxicol. Sci.;2017 01;155(1):3-21

- Dysregulation of lncRNAs has been implicated in various human health outcomes such as various cancers, Alzheimer 's disease, cardiovascular disease, autoimmune diseases, as well as intermediary metabolism such as glucose, lipid, and bile acid homeostasis.

5 - [0, 0, 0, 1] Environmental factors, epigenetics, and developmental origin of reproductive disorders.
[MEDLINE : 27421580]
(2017) Environmental factors, epigenetics, and developmental origin of reproductive disorders. Reproductive toxicology (Elmsford, N.Y.);Reprod. Toxicol.;2017 03;68:85-104

- Human data in support of & quot; Developmental Origins of Health and Disease & quot; (DOHaD) comes from multigenerational studies on offspring of diethylstilbestrol-exposed mothers/grandmothers.

5 - [0, 0, 0, 1] Lipophilic chemical exposure as a cause of type 2 diabetes (T2D).
[MEDLINE : 23509204]
(2013) Lipophilic chemical exposure as a cause of type 2 diabetes (T2D). Reviews on environmental health;Rev Environ Health;2013 ;28(1):9-20

- This hypothesis suggests that the T2D pandemic as well as the rapid increase of other environmental disease prevalence is, at least in part, due to sequential exposure to levels of lipophilic and hydrophilic environmental pollutants that are much lower than those currently believed to be toxic.


Associated Diseases - DID44631 : infertility

ZScoreRScoreEntity TypeIDNameSynonyms
3.01883413744 45 - [0, 0, 1, 4] Diseases DID44631 infertility infertility; Infertile; Difficulty conceiving

Evidence Section : DID44631 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] Estimation of plasma levels of bisphenol-A & phthalates in fertile & infertile women by gas chromatography-mass spectrometry.
[MEDLINE : 30778008]
(2018) Estimation of plasma levels of bisphenol-A & phthalates in fertile & infertile women by gas chromatography-mass spectrometry. The Indian journal of medical research;Indian J. Med. Res.;2018 Dec;148(6):734-742

- Estimation of plasma levels of bisphenol-A & amp; phthalates in fertile & amp; infertile women by gas chromatography-mass spectrometry.

5 - [0, 0, 0, 1] Melatonin protects prepuberal testis from deleterious effects of bisphenol A or diethylhexyl phthalate by preserving H3K9 methylation.
[MEDLINE : 29655234]
(2018) Melatonin protects prepuberal testis from deleterious effects of bisphenol A or diethylhexyl phthalate by preserving H3K9 methylation. Journal of pineal research;J. Pineal Res.;2018 Sep;65(2):e12497

- The deleterious effects of EDs on spermatogenesis have been well documented, whereas improvement of infertility associated with spermatogenesis defects remains a great challenge.

5 - [0, 0, 0, 1] Chronic exposure to bisphenol a impairs progesterone receptor-mediated signaling in the uterus during early pregnancy.
[MEDLINE : 28239613]
(2016) Chronic exposure to bisphenol a impairs progesterone receptor-mediated signaling in the uterus during early pregnancy. Receptors & clinical investigation;;2016 ;3(3):

- Whereas BPA has been linked to infertility and recurrent miscarriage in women, the impact of its exposure on uterine function during early pregnancy remains unclear.

5 - [0, 0, 0, 1] Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture.
[MEDLINE : 27107150]
(2016) Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture. Aquatic toxicology (Amsterdam, Netherlands);Aquat. Toxicol.;2016 Jun;175:286-98

- Exposure to environmental contaminants has been linked to developmental and reproductive abnormalities leading to infertility, spontaneous abortion, reduced number of offspring, and metabolic disorders.

5 - [0, 0, 0, 1] Chronic Exposure to Bisphenol A Affects Uterine Function During Early Pregnancy in Mice.
[MEDLINE : 27022677]
(2016) Chronic Exposure to Bisphenol A Affects Uterine Function During Early Pregnancy in Mice. Endocrinology;;2016 05;157(5):1764-74

- Although BPA has been linked to infertility and recurrent miscarriage in women, the impact of its exposure on uterine function during early pregnancy remains unclear.


Associated Diseases - DID40143 : Autistic thinking

ZScoreRScoreEntity TypeIDNameSynonyms
3.01883413744 45 - [0, 0, 1, 4] Diseases DID40143 Autistic thinking Autistic thinking; Autism

Evidence Section : DID40143 - MEDLINE

RScore Document Snippets
45 - [0, 0, 1, 4] Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products.
[MEDLINE : 27984170]
(2016) Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products. Neurochemistry international;Neurochem. Int.;2016 Oct;:

- Autism polymorphisms influence the sensitivity to some of these chemicals and these same genes play an important role in barrier function and control of respiratory cilia sweeping particulate matter from the airways.

- Further epidemiological studies and neurodevelopmental and behavioural research is warranted to determine the relevance of large number of suspect candidates whose addition to the environment, household, food and cosmetics might be fuelling the autism epidemic in a gene-dependent manner.

- Gene/environment interactions in autism were analysed using 206 autism susceptibility genes (ASG 's) from the Autworks database to interrogate ∼1 million chemical/gene interactions in the comparative toxicogenomics database.

- Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products.

- The increasing incidence of autism suggests a major environmental influence.


Associated Diseases - DID49494 : Generalized metabolic disorder

ZScoreRScoreEntity TypeIDNameSynonyms
2.45158020665 40 - [0, 0, 1, 3] Diseases DID49494 Generalized metabolic disorder Generalized metabolic disorder; METABOLIC DISORDERS; Diseases, Metabolic; Metabolic disease; Thesaurismosis; Metabolic disorder; Thesaurismoses; Metabolic Diseases; metabolism disorder; Disease, Metabolic; Disease of metabolism

Evidence Section : DID49494 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] Bisphenol A Exposure May Induce Hepatic Lipid Accumulation via Reprogramming the DNA Methylation Patterns of Genes Involved in Lipid Metabolism.
[MEDLINE : 27502578]
(2016) Bisphenol A Exposure May Induce Hepatic Lipid Accumulation via Reprogramming the DNA Methylation Patterns of Genes Involved in Lipid Metabolism. Scientific reports;Sci Rep;2016 08;6:31331

- Accumulating evidence suggests a role of bisphenol A (BPA) in metabolic disorders.

5 - [0, 0, 0, 1] Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture.
[MEDLINE : 27107150]
(2016) Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture. Aquatic toxicology (Amsterdam, Netherlands);Aquat. Toxicol.;2016 Jun;175:286-98

- Exposure to environmental contaminants has been linked to developmental and reproductive abnormalities leading to infertility, spontaneous abortion, reduced number of offspring, and metabolic disorders.

5 - [0, 0, 0, 1] The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins.
[MEDLINE : 26164745]
(2015) The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins. Environmental toxicology and pharmacology;Environ. Toxicol. Pharmacol.;2015 Jul;40(1):284-91

- The alteration of nutritional intake and fat metabolism may affect the maintenance of pregnancy and supplementation of nutrients to the fetus, and therefore can cause severe metabolic diseases such as ketosis, marasmus and diabetes mellitus in pregnant individuals.

5 - [0, 0, 0, 1] Health risk of exposure to Bisphenol A (BPA).
[MEDLINE : 25813067]
(2015) Health risk of exposure to Bisphenol A (BPA). Roczniki Panstwowego Zakladu Higieny;Rocz Panstw Zakl Hig;2015 ;66(1):5-11

- Therefore, BPA has been shown to play a role in the pathogenesis of several endocrine disorders including female and male infertility, precocious puberty, hormone dependent tumours such as breast and prostate cancer and several metabolic disorders including polycystic ovary syndrome (PCOS).


Associated Diseases - DID06067 : Fibroid

ZScoreRScoreEntity TypeIDNameSynonyms
2.45158020665 40 - [0, 0, 1, 3] Diseases DID06067 Fibroid Fibroid; Fibromyoma; Leiomyomatous Neoplasm; Leiomyoma; Fibromyomas; Leiomyomatous neoplasms; Fibroids; Fibroid Tumors; Fibroid Tumor; fibroid; Leiomyomas; Leiomyomatous Tumor; Leiomyoma nos (morphologic abnormality); Leiomyomatous neoplasm (morphologic abnormality); Leiomyomatous neoplasm nos (morphologic abnormality)

Evidence Section : DID06067 - MEDLINE

RScore Document Snippets
40 - [0, 0, 1, 3] Bisphenol A, benzophenone-type ultraviolet filters, and phthalates in relation to uterine leiomyoma.
[MEDLINE : 25531814]
(2015) Bisphenol A, benzophenone-type ultraviolet filters, and phthalates in relation to uterine leiomyoma. Environmental research;Environ. Res.;2015 Feb;137:101-7

- There was a lack of an association between select nonpersistent chemicals and the odds of a fibroid diagnosis.

- Mono-methyl phthalate levels were significantly lower in women with than without fibroids (1.78µg/g vs. 2.40µg/g).

- Significantly higher geometric mean creatinine-corrected concentrations of BPA, 2,4OH-BP, and 2OH-4MeO-BP were observed in women with than without fibroids [BPA: 2.09µg/g vs. 1.46µg/g p=0.004; 2,4OH-BP:11.10µg/g vs. 6.71µg/g p=0.01; 2OH-4MeO-BP: 11.31µg/g vs. 6.10µg/g p=0.01].

- Urinary concentrations of bisphenol A (BPA), five benzophenone-type UV filters (2-hydroxy-4-methoxybenzophenone (2OH-4MeO-BP), 2,4-dihydroxybenzophenone (2,4OH-BP), 2,2׳-dihydroxybenzophenone (2,2׳OH-4MeO-BP), 2,2׳4,4׳-tetrahydroxybenzophenone (2,2׳4,4׳OH-BP), and 4-hydroxybenzophenone (4OH-BP), and 14 phthalate monoesters were quantified in 495 women who later underwent laparoscopy/laparotomy at 14 clinical sites for the diagnosis of fibroids.


Associated Diseases - DID66820 : Sudek's Atrophy

ZScoreRScoreEntity TypeIDNameSynonyms
1.88432627585 35 - [0, 0, 0, 7] Diseases DID66820 Sudek's Atrophy Sudek's Atrophy; Shoulder-hand syndrome; Reflex sympathetic dystrophy; Sudek's atrophy; Complex Regional Pain Syndrome, Type I; Sudeck's atrophy; RSD - Reflex sympathetic dystrophy; Complex regional pain syndrome type I; REFLEX SYMPATHETIC DYSTROPHY SYNDROME; Reflex Sympathetic Dystrophies; Sympathetic Reflex Dystrophia; Type I Complex Regional Pain Syndrome; Shoulder Hand Syndrome; RSDs; Shoulder-Hand Syndromes; Reflex Neurovascular Dystrophy

Evidence Section : DID66820 - MEDLINE

RScore Document Snippets
5 - [0, 0, 0, 1] A nanoporous carbon derived from bimetallic organic-framework for magnetic solid-phase extraction of bisphenol analogs.
[MEDLINE : 31171210]
(2019) A nanoporous carbon derived from bimetallic organic-framework for magnetic solid-phase extraction of bisphenol analogs. Talanta;Talanta;2019 Sep;202:479-485

- The limits of detection for BPs were as low as 0.03-0.07 ng mg < sup > -1 < /sup > with the RSDs of less than 4.6 %.

5 - [0, 0, 0, 1] [Simultaneous determination of perfluoric acid, perfluorooctane sulfonic acid, bisphenol A, nonylphenol in infant milk powder by high-performance liquid chromatography-tandem mass spectrometry].
[MEDLINE : 30574706]
(2018) [Simultaneous determination of perfluoric acid, perfluorooctane sulfonic acid, bisphenol A, nonylphenol in infant milk powder by high-performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography;Se Pu;2018 Dec;36(12):1279-1283

- The recoveries ranged from 86.1 % to 106.8 %, and the relative standard deviations (RSDs) were in the range from 2.87 % to 9.53 %.

5 - [0, 0, 0, 1] Analytical determination of bisphenol A (BPA) and bisphenol analogues in paper products by LC-MS/MS.
[MEDLINE : 30303764]
(2018) Analytical determination of bisphenol A (BPA) and bisphenol analogues in paper products by LC-MS/MS. Food additives &amp; contaminants. Part A, Chemistry, analysis, control, exposure &amp; risk assessment;Food Addit Contam Part A Chem Anal Control Expo Risk Assess;2018 Nov;35(11):2256-2269

- Absolute recoveries ranged from 71 to 115 % and precision in terms of reproducibility and repeatability (intra- and inter-day) yielded in relative standard deviations (RSDs) of less than 15.0 % and 17.4 %, respectively.

5 - [0, 0, 0, 1] Supramolecular solvents combined with layered double hydroxide-coated magnetic nanoparticles for extraction of bisphenols and 4-tert-octylphenol from fruit juices.
[MEDLINE : 28764080]
(2017) Supramolecular solvents combined with layered double hydroxide-coated magnetic nanoparticles for extraction of bisphenols and 4-tert-octylphenol from fruit juices. Food chemistry;Food Chem;2017 Dec;237:870-876

- The intra-day and inter-day precision (RSDs %) for bisphenols (BPs) and 4-TOP at 100 and 300μgL < sup > -1 < /sup > were in the range of 4.0-7.8.

5 - [0, 0, 0, 1] [Preparation of molecularly imprinted polymers using dummy template and the applications in selective solid-phase extraction of seven bisphenols from human urine, bovine serum and beer samples].
[MEDLINE : 26387203]
Yang,Jiajia,J, Li,Yun,Y, Wang Jinchengt, Sun,Xiaoli,X, Chen,Jiping,J (2015) [Preparation of molecularly imprinted polymers using dummy template and the applications in selective solid-phase extraction of seven bisphenols from human urine, bovine serum and beer samples]. Se pu = Chinese journal of chromatography;Se Pu;2015 May;33(5):468-74

- The recoveries of the BPs spiked in blank samples at two spiked levels (100 and 500 µg/L for each BP) were in the range of 90.1 % -107.1 % with the RSDs ≤ 8.1 %.

5 - [0, 0, 0, 1] Selective and simultaneous determination of trace bisphenol A and tebuconazole in vegetable and juice samples by membrane-based molecularly imprinted solid-phase extraction and HPLC.
[MEDLINE : 24996366]
(2014) Selective and simultaneous determination of trace bisphenol A and tebuconazole in vegetable and juice samples by membrane-based molecularly imprinted solid-phase extraction and HPLC. Food chemistry;Food Chem;2014 Dec;164:527-35

- The recoveries of BPA and TBZ from different samples were higher than 70.33 % with RSDs lower than 9.57 %.

5 - [0, 0, 0, 1] Simultaneous determination of seven bisphenols in environmental water and solid samples by liquid chromatography-electrospray tandem mass spectrometry.
[MEDLINE : 24411090]
(2014) Simultaneous determination of seven bisphenols in environmental water and solid samples by liquid chromatography-electrospray tandem mass spectrometry. Journal of chromatography. A;J Chromatogr A;2014 Feb;1328:26-34

- Good method reproducibility was achieved in terms of intra- and inter-day precision, yielding relative standard deviations (RSDs) less than 16.9 and 18.1 %, respectively.


Associated Diseases - DID06289 : Ovarian Carcinoma

ZScoreRScoreEntity TypeIDNameSynonyms
1.88432627585 35 - [0, 0, 1, 2] Diseases DID06289 Ovarian Carcinoma Ovarian Carcinoma; Ovarian Cancers; CARCINOMA OF OVARY; Ovary Cancer; Cancer of the Ovary; Cancer of Ovary; Ovarian Cancer; Ovary Cancers; OVARIAN CARCINOMA; Cancer, Ovarian

Evidence Section : DID06289 - MEDLINE

RScore Document Snippets
35 - [0, 0, 1, 2] Bisphenol A and polychlorinated biphenyls enhance the cancer stem cell properties of human ovarian cancer cells by activating the WNT signaling pathway.
[MEDLINE : 31918092]
(2020) Bisphenol A and polychlorinated biphenyls enhance the cancer stem cell properties of human ovarian cancer cells by activating the WNT signaling pathway. Chemosphere;Chemosphere;2020 May;246:125775

- Nonetheless, most previous studies have focused on the toxic effects of these pollutants on the proliferation, metastasis and development of ovarian cancer cells.

- Many organic pollutants increase the risk of ovarian cancer depending on their estrogenic effects.

- Bisphenol A and polychlorinated biphenyls enhance the cancer stem cell properties of human ovarian cancer cells by activating the WNT signaling pathway.


Associated Diseases - DID47685 : Allergy

ZScoreRScoreEntity TypeIDNameSynonyms
1.88432627585 35 - [0, 0, 1, 2] Diseases DID47685 Allergy Allergy; Hypersensitivity reaction type i disease; Hypersensitivity

Evidence Section : DID47685 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy.
[MEDLINE : 25445825]
(2015) Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy. The Journal of allergy and clinical immunology;J. Allergy Clin. Immunol.;2015 Feb;135(2):370-8

- Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy.

5 - [0, 0, 0, 1] Role of estrogen receptors α and β in the development of allergic airway inflammation in mice: A possible involvement of interleukin 33 and eosinophils.
[MEDLINE : 30445053]
(2019) Role of estrogen receptors α and β in the development of allergic airway inflammation in mice: A possible involvement of interleukin 33 and eosinophils. Toxicology;Toxicology;2019 01;411:93-100

- Our findings indicate that ERα and ERβ are involved in the proinflammatory response in respiratory allergy, and their effects may be mediated by an increase in the expression of IL-33 and infiltration of eosinophils.

5 - [0, 0, 0, 1] Hypersensitivity to diethylstilbestrol. Cross-sensitization to dienestrol, hexestrol, bisphenol A, p-benzyl-phenol, hydroquinone-monobenzylether, and p-hydroxybenzoic-benzylester.
[MEDLINE : 13701662]
FREGERT,S,S, RORSMAN,H,H (1960) Hypersensitivity to diethylstilbestrol. Cross-sensitization to dienestrol, hexestrol, bisphenol A, p-benzyl-phenol, hydroquinone-monobenzylether, and p-hydroxybenzoic-benzylester. Acta dermato-venereologica;Acta Derm. Venereol.;1960 ;40:206-19

- Hypersensitivity to diethylstilbestrol.


Associated Diseases - DID40352 : tumorigenesis

ZScoreRScoreEntity TypeIDNameSynonyms
1.31707234506 30 - [0, 0, 1, 1] Diseases DID40352 tumorigenesis tumorigenesis; oncogenesis; Tumorigenesis

Evidence Section : DID40352 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A.
[MEDLINE : 27334623]
(2016) Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A. Environmental and molecular mutagenesis;Environ. Mol. Mutagen.;2016 07;57(6):435-46

- Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A.

5 - [0, 0, 0, 1] Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease.
[MEDLINE : 32796699]
(2020) Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease. International journal of molecular sciences;;2020 Aug;21(16):

- Due to its hormone-like properties, BPA may bind to estrogen receptors, thereby affecting both body weight and tumorigenesis.


Associated Diseases - DID59006 : genotoxicity

ZScoreRScoreEntity TypeIDNameSynonyms
1.31707234506 30 - [0, 0, 1, 1] Diseases DID59006 genotoxicity genotoxicity

Evidence Section : DID59006 - MEDLINE

RScore Document Snippets
30 - [0, 0, 1, 1] In vitro study to evaluate the cytotoxicity of BPA analogues based on their oxidative and genotoxic potential using human peripheral blood cells.
[MEDLINE : 31173877]
(2019) In vitro study to evaluate the cytotoxicity of BPA analogues based on their oxidative and genotoxic potential using human peripheral blood cells. Toxicology in vitro : an international journal published in association with BIBRA;Toxicol In Vitro;2019 Jun;60:229-236

- Therefore, bisphenols were found capable of inducing cytotoxicity via oxidative stress and genotoxicity.

- Although Bisphenol-A (BPA) has been found to exhibit toxicological properties such as genotoxicity and oxidative stress, yet there is very little data available on its analogues.


Associated Diseases - DID07248 : Osteosarcoma

ZScoreRScoreEntity TypeIDNameSynonyms
1.31707234506 30 - [0, 0, 1, 1] Diseases DID07248 Osteosarcoma Osteosarcoma; Mouse Osteosarcoma

Evidence Section : DID07248 - MEDLINE

RScore Document Snippets
30 - [0, 0, 1, 1] Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S.
[MEDLINE : 25912373]
(2015) Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S. Toxicology in vitro : an international journal published in association with BIBRA;Toxicol In Vitro;2015 Aug;29(5):1060-9

- To elucidate genome-wide gene expression responses, estrogen-dependent osteosarcoma cells were cultured with 10 nM BPA, BPAF, or BPS, for 8 h and 3 months.

- Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S.


Associated Diseases - DID06945 : LIVER FATTY CHANGE

ZScoreRScoreEntity TypeIDNameSynonyms
1.31707234506 30 - [0, 0, 1, 1] Diseases DID06945 LIVER FATTY CHANGE LIVER FATTY CHANGE; Liver Steatosis; hepatic steatosis; Steatosis of liver; Hepatic lipidosis; STEATOSIS HEPATIC; LIVER FATTY; Liver, Fatty; LIVER FATTY DEGENERATION; Fatty change of liver; Fatty liver disease; Alcoholic fatty liver; Steatosis of liver (disorder)

Evidence Section : DID06945 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?
[MEDLINE : 30359670]
(2018) Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?. Life sciences;Life Sci;2018 Dec;214:136-144

- Obesity, hepatic steatosis, impaired insulin signaling and pancreatic islet function could be the main results of Bisphenol A exposure.

5 - [0, 0, 0, 1] Xenobiotic-contaminated diets affect hepatic lipid metabolism: Implications for liver steatosis in Sparus aurata juveniles.
[MEDLINE : 26382854]
(2015) Xenobiotic-contaminated diets affect hepatic lipid metabolism: Implications for liver steatosis in Sparus aurata juveniles. Aquatic toxicology (Amsterdam, Netherlands);Aquat. Toxicol.;2015 Oct;167:257-64

- Xenobiotic-contaminated diets affect hepatic lipid metabolism: Implications for liver steatosis in Sparus aurata juveniles.


Associated Diseases - DID31595 : Diabetes Mellitus, Type II

ZScoreRScoreEntity TypeIDNameSynonyms
1.31707234506 30 - [0, 0, 1, 1] Diseases DID31595 Diabetes Mellitus, Type II Diabetes Mellitus, Type II; MODY; DIABETES, MATURITY ONSET; Diabetes Mellitus, Non Insulin Dependent; NIDDM - Non-insulin dependent diabetes mellitus; Diabetes Mellitus, Type 2; AODM; Type 2 diabetes mellitus; ketosis resistant diabetes; ADULT ONSET DIABETES MELLITUS; Non-insulin dependent diabetes mellitus; DIABETES MELLITUS, NON-INSULIN DEPENDENT; type II diabetes mellitus; Non-Insulin Dependent Diabetes; Adult-Onset Diabetes Mellitus; Non-Insulin-Dependent Diabetes Mellitus; noninsulin dependent diabetes mellitus; Stable Diabetes Mellitus; Maturity onset diabetes; DIABETES MELLITUS, TYPE II; NIDDM; Diabetes Mellitus, Non-Insulin-Dependent; Ketosis-Resistant Diabetes Mellitus; Maturity-Onset Diabetes Mellitus; Type II Diabetes; Diabetes mellitus type II; Maturity Onset Diabetes Mellitus; Diabetes mellitus type 2; Vasopressin-Sensitive Diabetes Insipidus; Maturity-onset diabetes of the young; Mason-type diabetes

Evidence Section : DID31595 - MEDLINE

RScore Document Snippets
30 - [0, 0, 1, 1] Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes.
[MEDLINE : 31004310]
(2019) Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes. Molecular and cellular biochemistry;Mol. Cell. Biochem.;2019 Aug;458(1-2):171-183

- There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM).

- While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases.


Associated Diseases - DID32555 : Atopic neurodermatitis

ZScoreRScoreEntity TypeIDNameSynonyms
1.31707234506 30 - [0, 0, 1, 1] Diseases DID32555 Atopic neurodermatitis Atopic neurodermatitis; Atopic Dermatitis; Disseminated neurodermatitis; Besnier's prurigo; ECZEMA, ATOPIC; Atopic Eczema; AD - Atopic dermatitis; DERMATITIS ALLERGIC; Allergic eczema; Allergic dermatitis; BESNIER PRURIGO; Eczema, allergic; DERMATITIS ATOPIC; Canine atopy; DERMATITIS, ATOPIC; Atopic Neurodermatitis; ECZEMA ATOPIC; Allergic (intrinsic) eczema (disorder); Atopic dermatitis (disorder); Atopic dermatitis nos (disorder); Atopic neurodermatitis (disorder); Besnier's prurigo (disorder)

Evidence Section : DID32555 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] Exposure to phthalates and bisphenol A are associated with atopic dermatitis symptoms in children: a time-series analysis.
[MEDLINE : 28274229]
(2017) Exposure to phthalates and bisphenol A are associated with atopic dermatitis symptoms in children: a time-series analysis. Environmental health : a global access science source;Environ Health;2017 03;16(1):24

- Exposure to phthalates and bisphenol A are associated with atopic dermatitis symptoms in children: a time-series analysis.

5 - [0, 0, 0, 1] Oral Administration of Bisphenol A Directly Exacerbates Allergic Airway Inflammation but Not Allergic Skin Inflammation in Mice.
[MEDLINE : 29846729]
(2018) Oral Administration of Bisphenol A Directly Exacerbates Allergic Airway Inflammation but Not Allergic Skin Inflammation in Mice. Toxicological sciences : an official journal of the Society of Toxicology;Toxicol. Sci.;2018 10;165(2):314-321

- Studies have indicated that BPA possibly exacerbates allergic diseases such as atopic dermatitis and asthma.


Associated Diseases - DID44658 : Asthma

ZScoreRScoreEntity TypeIDNameSynonyms
1.31707234506 30 - [0, 0, 1, 1] Diseases DID44658 Asthma Asthma

Evidence Section : DID44658 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] Exposure to bisphenol A and the development of asthma: A systematic review of cohort studies.
[MEDLINE : 27542534]
(2016) Exposure to bisphenol A and the development of asthma: A systematic review of cohort studies. Reproductive toxicology (Elmsford, N.Y.);Reprod. Toxicol.;2016 10;65:224-229

- Exposure to bisphenol A and the development of asthma: A systematic review of cohort studies.

5 - [0, 0, 0, 1] Oral Administration of Bisphenol A Directly Exacerbates Allergic Airway Inflammation but Not Allergic Skin Inflammation in Mice.
[MEDLINE : 29846729]
(2018) Oral Administration of Bisphenol A Directly Exacerbates Allergic Airway Inflammation but Not Allergic Skin Inflammation in Mice. Toxicological sciences : an official journal of the Society of Toxicology;Toxicol. Sci.;2018 10;165(2):314-321

- Studies have indicated that BPA possibly exacerbates allergic diseases such as atopic dermatitis and asthma.


Associated Diseases - DID44887 : Abnormal hepatic function

ZScoreRScoreEntity TypeIDNameSynonyms
1.31707234506 30 - [0, 0, 1, 1] Diseases DID44887 Abnormal hepatic function Abnormal hepatic function; Hepatic dysfunction; Liver Dysfunction; Abnormal liver function; Liver Dysfunctions; Dysfunction, Liver

Evidence Section : DID44887 - MEDLINE

RScore Document Snippets
30 - [0, 0, 1, 1] Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes.
[MEDLINE : 26922413]
(2016) Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes. Environmental research;Environ. Res.;2016 May;147:324-30

- Furthermore, the risk score composed of 4 risky pair of haplotypes showed interactive effect with BPA on abnormal liver function (p=0.0057).

- Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes.


Review Search Parameters

Parameter Name Values
sid

1656038392

timestamp

2022-06-23 04:28:56

query

Bisphenol A

action

association

status

Complete

query type toxin : T3D0637
target types disease : 19
found hits

19

doc count medline : 300
total hits

300

max hits

2000

synonyms bisphenol-a :


This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.