PolySearch2 - Given Bisphenol A, Find


ZScore RScore Entity ID Name Synonyms Hits
16.46 205 DID06582 breast neoplasm breast neoplasm; Breast tumour; Neoplasm of breast; Breast Neoplasm; Tumors, Breast; Breast Tumor; Tumor of the Breast; Tumor, Breast; mammary tumor; Breast Neoplasms; Tumor of breast; Tumour of breas... (Read More) 25 [0, 0, 4, 21]
14.22 180 DID71361 Obesity Obesity... (Read More) 15 [0, 1, 3, 11]
11.98 155 DID38503 Diabetes mellitus Diabetes mellitus; DM - Diabetes mellitus; diabetes; Diabetes mellitus (disorder); Diabetes nos... (Read More) 15 [0, 0, 4, 11]
5.27 80 DID55595 malignant tumoral disease malignant tumoral disease; Malignant neoplastic disease; Cancer morphology; Malignant tumor morphology; malignant tumor; Malignant Neoplasms; neoplasm/cancer; Malignant neoplasm; Malignant tumour; Tum... (Read More) 12 [0, 0, 1, 11]
3.92 65 DID70477 Disease Disease... (Read More) 13 [0, 0, 0, 13]
3.47 60 DID31595 Diabetes Mellitus, Type II Diabetes Mellitus, Type II; MODY; DIABETES, MATURITY ONSET; Diabetes Mellitus, Non Insulin Dependent; NIDDM - Non-insulin dependent diabetes mellitus; Diabetes Mellitus, Type 2; AODM; Type 2 diabetes ... (Read More) 4 [0, 0, 2, 2]
3.03 55 DID66820 Sudek's Atrophy Sudek's Atrophy; Shoulder-hand syndrome; Reflex sympathetic dystrophy; Sudek's atrophy; Complex Regional Pain Syndrome, Type I; Sudeck's atrophy; RSD - Reflex sympathetic dystrophy; Complex regional p... (Read More) 11 [0, 0, 0, 11]
3.03 55 DID23789 Stein-Leventhal Syndrome Stein-Leventhal Syndrome; POLYCYSTIC OVARIAN SYNDROME; Stein Leventhal Syndrome; Sclerocystic ovary syndrome; STEIN-LEVENTHAL SYNDROME; Polycystic ovarian disease; PCOD - Polycystic ovarian disease; P... (Read More) 7 [0, 0, 1, 6]
3.03 55 DID37448 Metabolic syndrome Metabolic syndrome; metabolic syndrome... (Read More) 3 [0, 0, 2, 1]
2.58 50 DID38589 Secondary Neoplasm Secondary Neoplasm; METS; Secondary Cancer; metastatic disease; Metastatic Neoplasm; Metastasize; Secondary Tumor; Secondary malignant deposit; Metastatic malignant disease; Metastatic Tumor; Secondar... (Read More) 6 [0, 0, 1, 5]
2.58 50 DID41130 Hormone disorders Hormone disorders; ENDOCRINE PROBLEM; Endocrine Diseases; Endocrine System Diseases; Endocrine disturbance; Hormone disturbance; Disease, Endocrine; Endocrine disorders; endocrine disorder; Diseases, ... (Read More) 6 [0, 0, 1, 5]
2.13 45 DID40143 Autistic thinking Autistic thinking; Autism... (Read More) 5 [0, 0, 1, 4]
1.68 40 DID06945 LIVER FATTY CHANGE LIVER FATTY CHANGE; Liver Steatosis; hepatic steatosis; Steatosis of liver; Hepatic lipidosis; STEATOSIS HEPATIC; LIVER FATTY; Liver, Fatty; LIVER FATTY DEGENERATION; Fatty change of liver; Fatty live... (Read More) 4 [0, 0, 1, 3]
1.68 40 DID49494 Generalized metabolic disorder Generalized metabolic disorder; METABOLIC DISORDERS; Diseases, Metabolic; Metabolic disease; Thesaurismosis; Metabolic disorder; Thesaurismoses; Metabolic Diseases; metabolism disorder; Disease, Metab... (Read More) 4 [0, 0, 1, 3]
1.68 40 DID06067 Fibroid Fibroid; Fibromyoma; Leiomyomatous Neoplasm; Leiomyoma; Fibromyomas; Leiomyomatous neoplasms; Fibroids; Fibroid Tumors; Fibroid Tumor; fibroid; Leiomyomas; Leiomyomatous Tumor; Leiomyoma nos (morpholo... (Read More) 4 [0, 0, 1, 3]
1.24 35 DID44631 infertility infertility; Infertile; Difficulty conceiving... (Read More) 3 [0, 0, 1, 2]
1.24 35 DID69824 Autism spectrum disorder Autism spectrum disorder... (Read More) 3 [0, 0, 1, 2]
1.24 35 DID44658 Asthma Asthma... (Read More) 3 [0, 0, 1, 2]
1.24 35 DID47685 Allergy Allergy; Hypersensitivity reaction type i disease; Hypersensitivity... (Read More) 3 [0, 0, 1, 2]
1.24 35 DID65672 -endometriosis -endometriosis; ENDOMETRIOSIS; Endometrioses; Endometrial Growths; Endometrial Implants... (Read More) 3 [0, 0, 1, 2]

Associated Diseases - DID06582 : breast neoplasm

ZScoreRScoreEntity TypeIDNameSynonyms
16.4626158322 205 - [0, 0, 4, 21] Diseases DID06582 breast neoplasm breast neoplasm; Breast tumour; Neoplasm of breast; Breast Neoplasm; Tumors, Breast; Breast Tumor; Tumor of the Breast; Tumor, Breast; mammary tumor; Breast Neoplasms; Tumor of breast; Tumour of breast; Neoplasm of the Breast; Mammary Neoplasms; Breast Tumors; NEOPLASM BREAST; Neoplasm, Breast; Breast cancer; Breast cancer; Ca breast - nos; Malignant neoplasm of breast; Malignant tumor of the breast; Mammary cancer; Primary breast cancer

Evidence Section : DID06582 - MEDLINE

RScore Document Snippets
45 - [0, 0, 1, 4] Urban Endocrine Disruptors Targeting Breast Cancer Proteins.
[MEDLINE : 26700111]
(2016) Urban Endocrine Disruptors Targeting Breast Cancer Proteins. Chemical research in toxicology;Chem. Res. Toxicol.;2016 Feb;29(2):150-61

- Many of these compounds have been associated with a broad range of diseases including the development or increased susceptibility to breast cancer, the most prevalent cancer in women worldwide, according to the World Health Organization.

- Thus, this article presents a virtual high-throughput screening (vHTS) to evaluate the affinity of proteins related to breast cancer, such as ESR1, ERBB2, PGR, BCRA1, and SHBG, among others, with EDCs from urban sources.

- Urban Endocrine Disruptors Targeting Breast Cancer Proteins.

- In short, this work shows the potential of several EDCs to bind breast cancer associated proteins as a tool to prioritize compounds to perform in vitro analysis to benefit the regulation or exposure prevention by the general population.

- Some of the chemicals that exhibited the best affinity scores for breast cancer proteins in each category were 1,3,7,8-tetrachlorodibenzo-p-dioxin, bisphenol A derivatives, perfluorooctanesulfonic acid, and benzo (a) pyrene, for catalase, several proteins, sex hormone-binding globulin, and cytochrome P450 1A2, respectively.

30 - [0, 0, 1, 1] Repeated Exposure to 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), an Active Metabolite of Bisphenol A, Aggressively Stimulates Breast Cancer Cell Growth in an Estrogen Receptor <i>β</i> (ER<i>β</i>)-Dependent Manner.
[MEDLINE : 30552153]
(2019) Repeated Exposure to 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), an Active Metabolite of Bisphenol A, Aggressively Stimulates Breast Cancer Cell Growth in an Estrogen Receptor <i>β</i> (ER<i>β</i>)-Dependent Manner. Molecular pharmacology;Mol. Pharmacol.;2019 Mar;95(3):260-268

- We have focused on the biologic relationship between breast tumor promotion and MBP/BPA, because BPA is considered to be a human carcinogen owing to its breast tumor-promoting properties.

- Repeated Exposure to 4-Methyl-2,4-bis (4-hydroxyphenyl) pent-1-ene (MBP), an Active Metabolite of Bisphenol A, Aggressively Stimulates Breast Cancer Cell Growth in an Estrogen Receptor < i > β < /i > (ER < i > β < /i >) -Dependent Manner.

30 - [0, 0, 1, 1] Editor's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells.
[MEDLINE : 28591870]
(2017) Editor's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells. Toxicological sciences : an official journal of the Society of Toxicology;Toxicol. Sci.;2017 08;158(2):431-443

- These findings point to the importance of better understanding the risk of adverse effects from exposure to BPA alternatives, including hormone-dependent breast cancer.

- Editor 's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells.

25 - [0, 0, 0, 5] Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7.
[MEDLINE : 30616060]
(2019) Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7. Environmental pollution (Barking, Essex : 1987);Environ. Pollut.;2019 Mar;246:697-703

- Gene expression profiling showed that some genes related to breast cancer progression were upregulated, including THBS4, PPARGC1A, CREB5, COL5A3.

- Gene ontology (GO) analysis of the differentially expressed genes revealed the significantly changes in PI3K-Akt signaling pathway and extracellular matrix, which were related to the proliferation, migration and invasion of breast cancer cells.

- Besides, methylation status in promoter of breast cancer related genes CDH1, SFN, TNFRSF10C were also changed, which implied that BPS might play a role in the development of breast cancer.

- These results illustrated that BPS exposure might play roles in the progression of breast cancer.

- Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7.

25 - [0, 0, 1, 0] DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients.
[MEDLINE : 28505145]
(2017) DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients. Genes;Genes (Basel);2017 May;8(5):

- DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients.

15 - [0, 0, 0, 3] The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer.
[MEDLINE : 25339261]
(2015) The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer. Endocrine-related cancer;Endocr. Relat. Cancer;2015 Feb;22(1):R1-31

- This review documents the clinical use of estrogen for breast cancer treatment or estrogen replacement therapy (ERT) in postmenopausal hysterectomized women, which can either result in breast cancer cell growth or breast cancer regression.

- The symmetry of the clinical and laboratory studies now permits the creation of rules for the future clinical application of ERT or phytoestrogen supplements: a 5-year gap is necessary after menopause to permit the selection of estrogen-deprived breast cancer cell populations to cause them to become vulnerable to apoptotic cell death.

- The key to triggering apoptosis with estrogen is the selection of breast cancer cell populations that are resistant to long-term estrogen deprivation.

5 - [0, 0, 0, 1] Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish.
[MEDLINE : 30265984]
(2018) Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish. Chemosphere;Chemosphere;2018 Dec;213:559-567

- Moreover, the Kaplan-Meier survival analysis was performed using homologenes (MST1R, PIK3CB and PRKCD) of hub genes in human to evaluate whether exposure to bisphenols may adversely affect breast cancer.

5 - [0, 0, 0, 1] Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine‑disrupting chemicals.
[MEDLINE : 30226539]
(2018) Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine‑disrupting chemicals. Oncology reports;Oncol. Rep.;2018 Nov;40(5):2766-2777

- Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine‑disrupting chemicals.

5 - [0, 0, 0, 1] Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression.
[MEDLINE : 29783106]
(2018) Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression. Ecotoxicology and environmental safety;Ecotoxicol. Environ. Saf.;2018 Sep;160:1-9

- Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression.

5 - [0, 0, 0, 1] Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells.
[MEDLINE : 29093337]
(2017) Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells. Biological &amp; pharmaceutical bulletin;Biol. Pharm. Bull.;2017 ;40(11):1909-1916

- Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells.

5 - [0, 0, 0, 1] The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands.
[MEDLINE : 28703301]
(2018) The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands. Journal of cellular physiology;J. Cell. Physiol.;2018 Mar;233(3):2247-2256

- The identification of specific effects of these endocrine disruptors on ADAM10 and ADAM17 will help to provide a better understanding of their roles in cell signaling and proinflammatory processes, and provide new potential targets for treatment of reproductive or inflammatory diseases such as asthma or breast cancer that are promoted by xenoestrogens.

5 - [0, 0, 0, 1] Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk.
[MEDLINE : 26911702]
(2016) Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk. Hormones &amp; cancer;Horm Cancer;2016 08;7(4):241-51

- The recent rise in incidence of human breast cancer and decreased age of first detection suggests a possible environmental etiology.

5 - [0, 0, 0, 1] Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors.
[MEDLINE : 26704594]
(2016) Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors. Journal of medicinal chemistry;J. Med. Chem.;2016 Jan;59(1):157-70

- The hypothesis is that in normal tissue the estrogenic SERM activity of a dual AI/SERM could attenuate the undesired effects stemming from global estrogen depletion caused by the AI activity of a dual AI/SERM, while in breast cancer tissue the antiestrogenic SERM activity of a dual AI/SERM could act synergistically with AI activity to enhance the antiproliferative effect.


Associated Diseases - DID71361 : Obesity

ZScoreRScoreEntity TypeIDNameSynonyms
14.2233683387 180 - [0, 1, 3, 11] Diseases DID71361 Obesity Obesity

Evidence Section : DID71361 - MEDLINE

RScore Document Snippets
55 - [0, 1, 0, 1] Obesity aggravates toxic effect of BPA on spermatogenesis.
[MEDLINE : 28501790]
(2017) Obesity aggravates toxic effect of BPA on spermatogenesis. Environment international;Environ Int;2017 08;105:56-65

- Obesity aggravates toxic effect of BPA on spermatogenesis.

- Both bisphenol A (BPA) and obesity affect male reproductive system.

25 - [0, 0, 1, 0] Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?
[MEDLINE : 30359670]
(2018) Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?. Life sciences;Life Sci.;2018 Dec;214:136-144

- Obesity, hepatic steatosis, impaired insulin signaling and pancreatic islet function could be the main results of Bisphenol A exposure.

25 - [0, 0, 1, 0] Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health.
[MEDLINE : 29223775]
(2018) Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health. Environmental research;Environ. Res.;2018 02;161:505-511

- Both bisphenol A and phthalates have been suggested as playing a role in obesity epidemics.

25 - [0, 0, 1, 0] Urinary bisphenol A is associated with insulin resistance and obesity in reproductive-aged women.
[MEDLINE : 27801986]
(2017) Urinary bisphenol A is associated with insulin resistance and obesity in reproductive-aged women. Clinical endocrinology;Clin. Endocrinol. (Oxf);2017 Apr;86(4):506-512

- Urinary bisphenol A is associated with insulin resistance and obesity in reproductive-aged women.

10 - [0, 0, 0, 2] Low-dose pollutant mixture triggers metabolic disturbances in female mice leading to common and specific features as compared to a high-fat diet.
[MEDLINE : 28433925]
(2017) Low-dose pollutant mixture triggers metabolic disturbances in female mice leading to common and specific features as compared to a high-fat diet. The Journal of nutritional biochemistry;J. Nutr. Biochem.;2017 07;45:83-93

- However, it is important to determine if pollutants could exert metabolic defects without directly inducing obesity.

- Environmental pollutants are potential etiologic factors of obesity and diabetes that reach epidemic proportions worldwide.

5 - [0, 0, 0, 1] Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver.
[MEDLINE : 31683443]
(2020) Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver. Chemosphere;Chemosphere;2020 Feb;241:125092

- Environmental pollution is increasingly considered an important factor involved in the obesity incidence.

5 - [0, 0, 0, 1] Short and long-term effects of bisphenol S (BPS) exposure during pregnancy and lactation on plasma lipids, hormones, and behavior in rats.
[MEDLINE : 31003143]
(2019) Short and long-term effects of bisphenol S (BPS) exposure during pregnancy and lactation on plasma lipids, hormones, and behavior in rats. Environmental pollution (Barking, Essex : 1987);Environ. Pollut.;2019 Jul;250:312-322

- Furthermore, the increased preference for the fat-enriched diet suggests an increased risk for obesity and its health consequences in the long term.

5 - [0, 0, 0, 1] Effects of diethylene glycol dibenzoate and Bisphenol A on the lipid metabolism of Danio rerio.
[MEDLINE : 29723837]
(2018) Effects of diethylene glycol dibenzoate and Bisphenol A on the lipid metabolism of Danio rerio. The Science of the total environment;Sci. Total Environ.;2018 Sep;636:641-655

- Endocrine disrupting chemicals (EDCs) are known to disrupt normal metabolism and can influence the incidence of obesity in animals and humans.

5 - [0, 0, 0, 1] Obesogen effects after perinatal exposure of 4,4'-sulfonyldiphenol (Bisphenol S) in C57BL/6 mice.
[MEDLINE : 27241191]
(2016) Obesogen effects after perinatal exposure of 4,4'-sulfonyldiphenol (Bisphenol S) in C57BL/6 mice. Toxicology;Toxicology;2016 05;357-358:11-20

- BPS potentiated the obesity induced by a HFD by inducing the lipid storage linked to faster lipid plasma clearance.

5 - [0, 0, 0, 1] Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A.
[MEDLINE : 26521216]
(2015) Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A. Environment international;Environ Int;2015 Dec;85:352-79

- Up to date findings indicated the association of ClxBPA with metabolic conditions, such as obesity, lipid accumulation, and type 2 diabetes mellitus, particularly in in-vitro and in-vivo studies.

5 - [0, 0, 0, 1] Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts.
[MEDLINE : 25693136]
(2015) Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. PloS one;PLoS ONE;2015 ;10(2):e0118819

- BPA has become a target of intense public scrutiny following concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer.

5 - [0, 0, 0, 1] Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice.
[MEDLINE : 24959901]
(2014) Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice. PloS one;PLoS ONE;2014 ;9(6):e100214

- This term refers to a form of diabetes which typically develops in later life and is associated with obesity.

5 - [0, 0, 0, 1] Toxicogenomics in the 3T3-L1 cell line, a new approach for screening of obesogenic compounds.
[MEDLINE : 24848799]
(2014) Toxicogenomics in the 3T3-L1 cell line, a new approach for screening of obesogenic compounds. Toxicological sciences : an official journal of the Society of Toxicology;Toxicol. Sci.;2014 Aug;140(2):352-63

- The obesogen hypothesis states that together with an energy imbalance between calories consumed and calories expended, exposure to environmental compounds early in life or throughout lifetime might have an influence on obesity development.


Associated Diseases - DID38503 : Diabetes mellitus

ZScoreRScoreEntity TypeIDNameSynonyms
11.9841208451 155 - [0, 0, 4, 11] Diseases DID38503 Diabetes mellitus Diabetes mellitus; DM - Diabetes mellitus; diabetes; Diabetes mellitus (disorder); Diabetes nos

Evidence Section : DID38503 - MEDLINE

RScore Document Snippets
55 - [0, 0, 2, 1] Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?
[MEDLINE : 30359670]
(2018) Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?. Life sciences;Life Sci.;2018 Dec;214:136-144

- As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adipocyte and skeletal muscles.

- Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes.

- Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

25 - [0, 0, 1, 0] Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes.
[MEDLINE : 31004310]
(2019) Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes. Molecular and cellular biochemistry;Mol. Cell. Biochem.;2019 Aug;458(1-2):171-183

- Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes.

25 - [0, 0, 1, 0] Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes. A Pilot Study.
[MEDLINE : 28095285]
(2016) Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes. A Pilot Study. Central European journal of public health;Cent. Eur. J. Public Health;2016 12;24(4):297-301

- Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes.

15 - [0, 0, 0, 3] Lipophilic chemical exposure as a cause of type 2 diabetes (T2D).
[MEDLINE : 23509204]
(2013) Lipophilic chemical exposure as a cause of type 2 diabetes (T2D). Reviews on environmental health;Rev Environ Health;2013 ;28(1):9-20

- Recent research has shown that diabetes can be caused by exposure to persistent organic pollutants (POPs), exudates from common plastics, air pollution, primary and secondary tobacco smoke, and some pharmaceuticals.

- Lipophilic chemical exposure as a cause of type 2 diabetes (T2D).

- The prevalence of type 2 diabetes (T2D) is increasing worldwide in pandemic-like numbers.

10 - [0, 0, 0, 2] Urinary concentrations of environmental phenols and their association with type 2 diabetes in a population in Jeddah, Saudi Arabia.
[MEDLINE : 29960220]
(2018) Urinary concentrations of environmental phenols and their association with type 2 diabetes in a population in Jeddah, Saudi Arabia. Environmental research;Environ. Res.;2018 10;166:544-552

- Urinary concentrations of environmental phenols and their association with type 2 diabetes in a population in Jeddah, Saudi Arabia.

- Unconditional logistic regression was performed to estimate odd ratios (ORs) for the association between diabetes and EDC exposures after adjusting for confounders including age, gender, nationality, smoking status and occupation.

5 - [0, 0, 0, 1] Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice.
[MEDLINE : 28962342]
(2015) Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice. Toxicology reports;Toxicol Rep;2015 ;2:99-110

- Previous observations that BPA exposure increased the prevalence of diabetes and insulitis and decreased the number of tissue resident macrophages in pancreas were confirmed, and extended by demonstrating that BPA exposure also impaired the phagocytic activity of peritoneal macrophages.

5 - [0, 0, 0, 1] Low-dose pollutant mixture triggers metabolic disturbances in female mice leading to common and specific features as compared to a high-fat diet.
[MEDLINE : 28433925]
(2017) Low-dose pollutant mixture triggers metabolic disturbances in female mice leading to common and specific features as compared to a high-fat diet. The Journal of nutritional biochemistry;J. Nutr. Biochem.;2017 07;45:83-93

- Environmental pollutants are potential etiologic factors of obesity and diabetes that reach epidemic proportions worldwide.

5 - [0, 0, 0, 1] The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins.
[MEDLINE : 26164745]
(2015) The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins. Environmental toxicology and pharmacology;Environ. Toxicol. Pharmacol.;2015 Jul;40(1):284-91

- The alteration of nutritional intake and fat metabolism may affect the maintenance of pregnancy and supplementation of nutrients to the fetus, and therefore can cause severe metabolic diseases such as ketosis, marasmus and diabetes mellitus in pregnant individuals.

5 - [0, 0, 0, 1] Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts.
[MEDLINE : 25693136]
(2015) Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. PloS one;PLoS ONE;2015 ;10(2):e0118819

- BPA has become a target of intense public scrutiny following concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer.

5 - [0, 0, 0, 1] Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice.
[MEDLINE : 24959901]
(2014) Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice. PloS one;PLoS ONE;2014 ;9(6):e100214

- This term refers to a form of diabetes which typically develops in later life and is associated with obesity.


Associated Diseases - DID55595 : malignant tumoral disease

ZScoreRScoreEntity TypeIDNameSynonyms
5.26637836446 80 - [0, 0, 1, 11] Diseases DID55595 malignant tumoral disease malignant tumoral disease; Malignant neoplastic disease; Cancer morphology; Malignant tumor morphology; malignant tumor; Malignant Neoplasms; neoplasm/cancer; Malignant neoplasm; Malignant tumour; Tumor, malignant; Neoplasms - malignant; CA - Cancer; NEOPLASM MALIGNANT; Cancer; Primary cancer

Evidence Section : DID55595 - MEDLINE

RScore Document Snippets
35 - [0, 0, 1, 2] Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17.
[MEDLINE : 30065191]
(2018) Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17. International journal of molecular sciences;Int J Mol Sci;2018 Jul;19(8):

- Exposure to BPA or NP is related to cell death, hormonal deregulation, and cancer onset.

- These results confirm the capacity of these compounds to induce cell apoptosis in cancer cell lines and uncover ADAM17 as a key regulator of this process in response to EDCs.

- Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17.

10 - [0, 0, 0, 2] DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk.
[MEDLINE : 27415467]
(2016) DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk. Epigenetics;Epigenetics;2016 09;11(9):674-689

- Pathway analysis revealed cancer as the top common disease pathway.

- Furthermore, clustering analyses using the dataset from The Cancer Genome Atlas revealed that expression of this set of 7 genes was associated with recurrence-free survival of PCa patients.

5 - [0, 0, 0, 1] Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish.
[MEDLINE : 30265984]
(2018) Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish. Chemosphere;Chemosphere;2018 Dec;213:559-567

- In addition, the results of KOBAS shown in 'Pathways in Cancer ' and 'Cancers ' belong to the top 10 terms in pathway enrichment analyses using genes related to BPF or BPS in human, as was found using GenCLiP.

5 - [0, 0, 0, 1] An integrative transcriptomic analysis reveals bisphenol A exposure-induced dysregulation of microRNA expression in human endometrial cells.
[MEDLINE : 28238728]
(2017) An integrative transcriptomic analysis reveals bisphenol A exposure-induced dysregulation of microRNA expression in human endometrial cells. Toxicology in vitro : an international journal published in association with BIBRA;Toxicol In Vitro;2017 Jun;41:133-142

- Aberrant microRNAs (miRNAs) regulation has been observed in the development of cancer.

5 - [0, 0, 0, 1] Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk.
[MEDLINE : 26911702]
(2016) Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk. Hormones &amp; cancer;Horm Cancer;2016 08;7(4):241-51

- We suggest that dysregulation of inflammatory cytokines, both pro-inflammatory and anti-inflammatory, leads to a microenvironment that may promote disordered cell growth through inhibition of the immune response that targets cancer cells.

5 - [0, 0, 0, 1] Urban Endocrine Disruptors Targeting Breast Cancer Proteins.
[MEDLINE : 26700111]
(2016) Urban Endocrine Disruptors Targeting Breast Cancer Proteins. Chemical research in toxicology;Chem. Res. Toxicol.;2016 Feb;29(2):150-61

- Many of these compounds have been associated with a broad range of diseases including the development or increased susceptibility to breast cancer, the most prevalent cancer in women worldwide, according to the World Health Organization.

5 - [0, 0, 0, 1] Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia.
[MEDLINE : 26654562]
(2016) Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia. Environmental research;Environ. Res.;2016 10;150:573-581

- Oxidative stress arises from excessive free radicals in the body and is a trigger for numerous diseases, such as cancer and atherosclerosis.

5 - [0, 0, 0, 1] Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts.
[MEDLINE : 25693136]
(2015) Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. PloS one;PLoS ONE;2015 ;10(2):e0118819

- BPA has become a target of intense public scrutiny following concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer.

5 - [0, 0, 0, 1] The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer.
[MEDLINE : 25339261]
(2015) The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer. Endocrine-related cancer;Endocr. Relat. Cancer;2015 Feb;22(1):R1-31

- The successful use of high-dose synthetic estrogens to treat postmenopausal metastatic breast cancer is the first effective 'chemical therapy ' proven in clinical trial to treat any cancer.


Associated Diseases - DID70477 : Disease

ZScoreRScoreEntity TypeIDNameSynonyms
3.92282986833 65 - [0, 0, 0, 13] Diseases DID70477 Disease Disease

Evidence Section : DID70477 - MEDLINE

RScore Document Snippets
10 - [0, 0, 0, 2] Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A.
[MEDLINE : 27334623]
(2016) Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A. Environmental and molecular mutagenesis;Environ. Mol. Mutagen.;2016 07;57(6):435-46

- This work demonstrated that epigenome-wide discovery experiments in animal models were effective tools for identification and understanding of paralagous epimutations salient to human disease.

- These tumors represent early-onset disease and lack classical sexual dimorphism in incidence.

5 - [0, 0, 0, 1] Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver.
[MEDLINE : 31683443]
(2020) Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver. Chemosphere;Chemosphere;2020 Feb;241:125092

- Endocrine disruptors (EDs) are important actors in the concept of DOHaD (Developmental Origins of Health and Disease), where epigenetic mechanisms play crucial roles.

5 - [0, 0, 0, 1] Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism.
[MEDLINE : 28567415]
(2017) Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism. International journal of genomics;Int J Genomics;2017 ;2017:7526592

- The Developmental Origin of Health and Disease (DOHaD) hypothesizes that the environment during fetal and childhood development affects the risk for many chronic diseases in later stages of life, including neurodevelopmental disorders.

5 - [0, 0, 0, 1] Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases.
[MEDLINE : 27983596]
(2016) Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases. International journal of molecular sciences;Int J Mol Sci;2016 Dec;17(12):

- Some of these genes are involved with brain diseases, such as Alzheimer 's Disease (AD), Parkinson 's Disease, Huntington 's Disease, Amyotrophic Lateral Sclerosis, Autism Spectrum Disorder, and Brain Neoplasms.

5 - [0, 0, 0, 1] Long Non-Coding RNAs: A Novel Paradigm for Toxicology.
[MEDLINE : 27864543]
(2017) Long Non-Coding RNAs: A Novel Paradigm for Toxicology. Toxicological sciences : an official journal of the Society of Toxicology;Toxicol. Sci.;2017 01;155(1):3-21

- Dysregulation of lncRNAs has been implicated in various human health outcomes such as various cancers, Alzheimer 's disease, cardiovascular disease, autoimmune diseases, as well as intermediary metabolism such as glucose, lipid, and bile acid homeostasis.

5 - [0, 0, 0, 1] Environmental factors, epigenetics, and developmental origin of reproductive disorders.
[MEDLINE : 27421580]
(2017) Environmental factors, epigenetics, and developmental origin of reproductive disorders. Reproductive toxicology (Elmsford, N.Y.);Reprod. Toxicol.;2017 03;68:85-104

- Human data in support of & quot; Developmental Origins of Health and Disease & quot; (DOHaD) comes from multigenerational studies on offspring of diethylstilbestrol-exposed mothers/grandmothers.

5 - [0, 0, 0, 1] DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk.
[MEDLINE : 27415467]
(2016) DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk. Epigenetics;Epigenetics;2016 09;11(9):674-689

- Pathway analysis revealed cancer as the top common disease pathway.

5 - [0, 0, 0, 1] Zebrafish embryos as a screen for DNA methylation modifications after compound exposure.
[MEDLINE : 26712470]
(2016) Zebrafish embryos as a screen for DNA methylation modifications after compound exposure. Toxicology and applied pharmacology;Toxicol. Appl. Pharmacol.;2016 Jan;291:84-96

- Modified epigenetic programming early in life is proposed to underlie the development of an adverse adult phenotype, known as the Developmental Origins of Health and Disease (DOHaD) concept.

5 - [0, 0, 0, 1] CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson's disease mice.
[MEDLINE : 24995576]
(2014) CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson's disease mice. Chemico-biological interactions;Chem. Biol. Interact.;2014 Sep;220:149-57

- Parkinson 's disease (PD) is characterized by the progressive degeneration via apoptosis of nigrostriatal dopaminergic neurons associated with inflammation, resulting in behavioral anomalies.

5 - [0, 0, 0, 1] Maternal bisphenol a exposure impacts the fetal heart transcriptome.
[MEDLINE : 24586524]
(2014) Maternal bisphenol a exposure impacts the fetal heart transcriptome. PloS one;PLoS ONE;2014 ;9(2):e89096

- Conditions during fetal development influence health and disease in adulthood, especially during critical windows of organogenesis.

5 - [0, 0, 0, 1] [A memoir of my researches on xenobiotic metabolism for 48 years--researches on Kanemi Yusho and endocrine disrupting chemicals].
[MEDLINE : 23811764]
(2013) [A memoir of my researches on xenobiotic metabolism for 48 years--researches on Kanemi Yusho and endocrine disrupting chemicals]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan;Yakugaku Zasshi;2013 ;133(7):747-72

- In 1968, an epidemic of a & quot; strange disease & quot;, called Yusho, occurred in western Japan.

5 - [0, 0, 0, 1] Lipophilic chemical exposure as a cause of type 2 diabetes (T2D).
[MEDLINE : 23509204]
(2013) Lipophilic chemical exposure as a cause of type 2 diabetes (T2D). Reviews on environmental health;Rev Environ Health;2013 ;28(1):9-20

- This hypothesis suggests that the T2D pandemic as well as the rapid increase of other environmental disease prevalence is, at least in part, due to sequential exposure to levels of lipophilic and hydrophilic environmental pollutants that are much lower than those currently believed to be toxic.


Associated Diseases - DID31595 : Diabetes Mellitus, Type II

ZScoreRScoreEntity TypeIDNameSynonyms
3.47498036962 60 - [0, 0, 2, 2] Diseases DID31595 Diabetes Mellitus, Type II Diabetes Mellitus, Type II; MODY; DIABETES, MATURITY ONSET; Diabetes Mellitus, Non Insulin Dependent; NIDDM - Non-insulin dependent diabetes mellitus; Diabetes Mellitus, Type 2; AODM; Type 2 diabetes mellitus; ketosis resistant diabetes; ADULT ONSET DIABETES MELLITUS; Non-insulin dependent diabetes mellitus; DIABETES MELLITUS, NON-INSULIN DEPENDENT; type II diabetes mellitus; Non-Insulin Dependent Diabetes; Adult-Onset Diabetes Mellitus; Non-Insulin-Dependent Diabetes Mellitus; noninsulin dependent diabetes mellitus; Stable Diabetes Mellitus; Maturity onset diabetes; DIABETES MELLITUS, TYPE II; NIDDM; Diabetes Mellitus, Non-Insulin-Dependent; Ketosis-Resistant Diabetes Mellitus; Maturity-Onset Diabetes Mellitus; Type II Diabetes; Diabetes mellitus type II; Maturity Onset Diabetes Mellitus; Diabetes mellitus type 2; Vasopressin-Sensitive Diabetes Insipidus; Maturity-onset diabetes of the young; Mason-type diabetes

Evidence Section : DID31595 - MEDLINE

RScore Document Snippets
30 - [0, 0, 1, 1] Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes.
[MEDLINE : 31004310]
(2019) Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes. Molecular and cellular biochemistry;Mol. Cell. Biochem.;2019 Aug;458(1-2):171-183

- There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM).

- While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases.

25 - [0, 0, 1, 0] Urinary concentrations of environmental phenols and their association with type 2 diabetes in a population in Jeddah, Saudi Arabia.
[MEDLINE : 29960220]
(2018) Urinary concentrations of environmental phenols and their association with type 2 diabetes in a population in Jeddah, Saudi Arabia. Environmental research;Environ. Res.;2018 10;166:544-552

- A few epidemiologic studies suggest that exposure to bisphenol A (BPA) is associated with type 2 diabetes mellitus (T2DM).

5 - [0, 0, 0, 1] Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A.
[MEDLINE : 26521216]
(2015) Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A. Environment international;Environ Int;2015 Dec;85:352-79

- Up to date findings indicated the association of ClxBPA with metabolic conditions, such as obesity, lipid accumulation, and type 2 diabetes mellitus, particularly in in-vitro and in-vivo studies.


Associated Diseases - DID66820 : Sudek's Atrophy

ZScoreRScoreEntity TypeIDNameSynonyms
3.02713087091 55 - [0, 0, 0, 11] Diseases DID66820 Sudek's Atrophy Sudek's Atrophy; Shoulder-hand syndrome; Reflex sympathetic dystrophy; Sudek's atrophy; Complex Regional Pain Syndrome, Type I; Sudeck's atrophy; RSD - Reflex sympathetic dystrophy; Complex regional pain syndrome type I; REFLEX SYMPATHETIC DYSTROPHY SYNDROME; Reflex Sympathetic Dystrophies; Sympathetic Reflex Dystrophia; Type I Complex Regional Pain Syndrome; Shoulder Hand Syndrome; RSDs; Shoulder-Hand Syndromes; Reflex Neurovascular Dystrophy

Evidence Section : DID66820 - MEDLINE

RScore Document Snippets
5 - [0, 0, 0, 1] A nanoporous carbon derived from bimetallic organic-framework for magnetic solid-phase extraction of bisphenol analogs.
[MEDLINE : 31171210]
(2019) A nanoporous carbon derived from bimetallic organic-framework for magnetic solid-phase extraction of bisphenol analogs. Talanta;Talanta;2019 Sep;202:479-485

- The limits of detection for BPs were as low as 0.03-0.07 ng mg < sup > -1 < /sup > with the RSDs of less than 4.6 %.

5 - [0, 0, 0, 1] Magnetic nitrogen-doped reduced graphene oxide as a novel magnetic solid-phase extraction adsorbent for the separation of bisphenol endocrine disruptors in carbonated beverages.
[MEDLINE : 31122411]
(2019) Magnetic nitrogen-doped reduced graphene oxide as a novel magnetic solid-phase extraction adsorbent for the separation of bisphenol endocrine disruptors in carbonated beverages. Talanta;Talanta;2019 Aug;201:194-203

- The recoveries varied from 86.52 % to 101.47 % with relative standard deviations (RSDs) less than 8.59 %.

5 - [0, 0, 0, 1] [Simultaneous determination of perfluoric acid, perfluorooctane sulfonic acid, bisphenol A, nonylphenol in infant milk powder by high-performance liquid chromatography-tandem mass spectrometry].
[MEDLINE : 30574706]
(2018) [Simultaneous determination of perfluoric acid, perfluorooctane sulfonic acid, bisphenol A, nonylphenol in infant milk powder by high-performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography;Se Pu;2018 Dec;36(12):1279-1283

- The recoveries ranged from 86.1 % to 106.8 %, and the relative standard deviations (RSDs) were in the range from 2.87 % to 9.53 %.

5 - [0, 0, 0, 1] Analytical determination of bisphenol A (BPA) and bisphenol analogues in paper products by LC-MS/MS.
[MEDLINE : 30303764]
(2018) Analytical determination of bisphenol A (BPA) and bisphenol analogues in paper products by LC-MS/MS. Food additives &amp; contaminants. Part A, Chemistry, analysis, control, exposure &amp; risk assessment;Food Addit Contam Part A Chem Anal Control Expo Risk Assess;2018 Nov;35(11):2256-2269

- Absolute recoveries ranged from 71 to 115 % and precision in terms of reproducibility and repeatability (intra- and inter-day) yielded in relative standard deviations (RSDs) of less than 15.0 % and 17.4 %, respectively.

5 - [0, 0, 0, 1] Supramolecular solvents combined with layered double hydroxide-coated magnetic nanoparticles for extraction of bisphenols and 4-tert-octylphenol from fruit juices.
[MEDLINE : 28764080]
(2017) Supramolecular solvents combined with layered double hydroxide-coated magnetic nanoparticles for extraction of bisphenols and 4-tert-octylphenol from fruit juices. Food chemistry;Food Chem;2017 Dec;237:870-876

- The intra-day and inter-day precision (RSDs %) for bisphenols (BPs) and 4-TOP at 100 and 300μgL < sup > -1 < /sup > were in the range of 4.0-7.8.

5 - [0, 0, 0, 1] A hybrid material as a sorbent phase for the disposable pipette extraction technique enhances efficiency in the determination of phenolic endocrine-disrupting compounds.
[MEDLINE : 28734604]
(2017) A hybrid material as a sorbent phase for the disposable pipette extraction technique enhances efficiency in the determination of phenolic endocrine-disrupting compounds. Journal of chromatography. A;J Chromatogr A;2017 Sep;1513:42-50

- Limits of detection of 0.60μgL < sup > -1 < /sup > for 4-t-OP and 0.30μgL < sup > -1 < /sup > for other analytes, RSDs ranging from 1 to 20 % and relative recoveries of 83-116 % were obtained.

5 - [0, 0, 0, 1] Dispersive liquid-liquid microextraction for four phenolic environmental estrogens in water samples followed by determination using capillary electrophoresis.
[MEDLINE : 27067023]
(2016) Dispersive liquid-liquid microextraction for four phenolic environmental estrogens in water samples followed by determination using capillary electrophoresis. Electrophoresis;Electrophoresis;2016 10;37(19):2502-2508

- Recoveries ranging from 70.4 to 108.1 % were obtained with tap water, lake water and seawater samples spiked at three concentration levels and the relative standard deviations (RSDs, for n = 5) were 2.1-9.7 %.

5 - [0, 0, 0, 1] [Preparation of molecularly imprinted polymers using dummy template and the applications in selective solid-phase extraction of seven bisphenols from human urine, bovine serum and beer samples].
[MEDLINE : 26387203]
Yang,Jiajia,J, Li,Yun,Y, Wang Jinchengt, Sun,Xiaoli,X, Chen,Jiping,J (2015) [Preparation of molecularly imprinted polymers using dummy template and the applications in selective solid-phase extraction of seven bisphenols from human urine, bovine serum and beer samples]. Se pu = Chinese journal of chromatography;Se Pu;2015 May;33(5):468-74

- The recoveries of the BPs spiked in blank samples at two spiked levels (100 and 500 µg/L for each BP) were in the range of 90.1 % -107.1 % with the RSDs ≤ 8.1 %.

5 - [0, 0, 0, 1] Monitoring of selected estrogen mimics in complicated samples using polymeric ionic liquid-based multiple monolithic fiber solid-phase microextraction combined with high-performance liquid chromatography.
[MEDLINE : 25680551]
(2015) Monitoring of selected estrogen mimics in complicated samples using polymeric ionic liquid-based multiple monolithic fiber solid-phase microextraction combined with high-performance liquid chromatography. Journal of chromatography. A;J Chromatogr A;2015 Mar;1385:12-9

- Excellent method reproducibility was achieved by evaluating the repeatability, intermediate precision and MMF-to-MMF reproducibility with relative standard deviations (RSDs) of both less than 10 %.

5 - [0, 0, 0, 1] Selective and simultaneous determination of trace bisphenol A and tebuconazole in vegetable and juice samples by membrane-based molecularly imprinted solid-phase extraction and HPLC.
[MEDLINE : 24996366]
(2014) Selective and simultaneous determination of trace bisphenol A and tebuconazole in vegetable and juice samples by membrane-based molecularly imprinted solid-phase extraction and HPLC. Food chemistry;Food Chem;2014 Dec;164:527-35

- The recoveries of BPA and TBZ from different samples were higher than 70.33 % with RSDs lower than 9.57 %.

5 - [0, 0, 0, 1] Simultaneous determination of seven bisphenols in environmental water and solid samples by liquid chromatography-electrospray tandem mass spectrometry.
[MEDLINE : 24411090]
(2014) Simultaneous determination of seven bisphenols in environmental water and solid samples by liquid chromatography-electrospray tandem mass spectrometry. Journal of chromatography. A;J Chromatogr A;2014 Feb;1328:26-34

- Good method reproducibility was achieved in terms of intra- and inter-day precision, yielding relative standard deviations (RSDs) less than 16.9 and 18.1 %, respectively.


Associated Diseases - DID23789 : Stein-Leventhal Syndrome

ZScoreRScoreEntity TypeIDNameSynonyms
3.02713087091 55 - [0, 0, 1, 6] Diseases DID23789 Stein-Leventhal Syndrome Stein-Leventhal Syndrome; POLYCYSTIC OVARIAN SYNDROME; Stein Leventhal Syndrome; Sclerocystic ovary syndrome; STEIN-LEVENTHAL SYNDROME; Polycystic ovarian disease; PCOD - Polycystic ovarian disease; Polycystic Ovary Syndrome; Polycystic ovaries; polycystic ovary disease; PCOS; polycystic ovary disorder; Stein - Leventhal syndrome; polycystic ovary; Sclerocystic Ovarian Degeneration; Multicystic ovaries; Polycystic ovaries (disorder); Stein-leventhal synd.; Stein-leventhal synd.

Evidence Section : DID23789 - MEDLINE

RScore Document Snippets
50 - [0, 0, 1, 5] Urinary concentration of personal care products and polycystic ovary syndrome: A case-control study.
[MEDLINE : 30265948]
(2019) Urinary concentration of personal care products and polycystic ovary syndrome: A case-control study. Environmental research;Environ. Res.;2019 01;168:48-53

- We performed a case-control study to explore the association between the concentrations of certain emerging contaminants (organic UV filters, bisphenol A, and triclosan) and the risk of PCOS.

- Urinary concentration of personal care products and polycystic ovary syndrome: A case-control study.

- Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder among females of reproductive age.

- Urine samples were collected from 40 women with PCOS (case group) and 83 healthy women (control group).

- However, with stratification according to body mass index, one organic UV filter - octocrylene (OC) was significantly associated with PCOS in women with BMI ≥ 24 (adjusted OR = 1.512, 95 % CI: 1.043, 2.191).

- We conclude that there is positive association between OC and PCOS risk in obese and overweight women.

5 - [0, 0, 0, 1] Health risk of exposure to Bisphenol A (BPA).
[MEDLINE : 25813067]
(2015) Health risk of exposure to Bisphenol A (BPA). Roczniki Panstwowego Zakladu Higieny;Rocz Panstw Zakl Hig;2015 ;66(1):5-11

- Therefore, BPA has been shown to play a role in the pathogenesis of several endocrine disorders including female and male infertility, precocious puberty, hormone dependent tumours such as breast and prostate cancer and several metabolic disorders including polycystic ovary syndrome (PCOS).


Associated Diseases - DID37448 : Metabolic syndrome

ZScoreRScoreEntity TypeIDNameSynonyms
3.02713087091 55 - [0, 0, 2, 1] Diseases DID37448 Metabolic syndrome Metabolic syndrome; metabolic syndrome

Evidence Section : DID37448 - MEDLINE

RScore Document Snippets
30 - [0, 0, 1, 1] Association between Heavy Metals, Bisphenol A, Volatile Organic Compounds and Phthalates and Metabolic Syndrome.
[MEDLINE : 30823556]
(2019) Association between Heavy Metals, Bisphenol A, Volatile Organic Compounds and Phthalates and Metabolic Syndrome. International journal of environmental research and public health;Int J Environ Res Public Health;2019 02;16(4):

- Association between Heavy Metals, Bisphenol A, Volatile Organic Compounds and Phthalates and Metabolic Syndrome.

- The incidence of metabolic syndrome (MetS), which causes heart disease and stroke, has increased significantly worldwide.

25 - [0, 0, 1, 0] Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes. A Pilot Study.
[MEDLINE : 28095285]
(2016) Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes. A Pilot Study. Central European journal of public health;Cent. Eur. J. Public Health;2016 12;24(4):297-301

- Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes.


Associated Diseases - DID38589 : Secondary Neoplasm

ZScoreRScoreEntity TypeIDNameSynonyms
2.5792813722 50 - [0, 0, 1, 5] Diseases DID38589 Secondary Neoplasm Secondary Neoplasm; METS; Secondary Cancer; metastatic disease; Metastatic Neoplasm; Metastasize; Secondary Tumor; Secondary malignant deposit; Metastatic malignant disease; Metastatic Tumor; Secondary tumour; Metastatic Malignant Neoplasm; Tumor, metastatic; Neoplasm Metastases; Tumour metastasis; Tumor metastasis; metastatic cancer; cancer, metastatic; METC; Secondaries; Secondary malignancies; Secondary neoplasm; Tumor Cell Migration

Evidence Section : DID38589 - MEDLINE

RScore Document Snippets
50 - [0, 0, 1, 5] Association between Heavy Metals, Bisphenol A, Volatile Organic Compounds and Phthalates and Metabolic Syndrome.
[MEDLINE : 30823556]
(2019) Association between Heavy Metals, Bisphenol A, Volatile Organic Compounds and Phthalates and Metabolic Syndrome. International journal of environmental research and public health;Int J Environ Res Public Health;2019 02;16(4):

- Although many studies have revealed the relationship between heavy metals (cadmium, mercury, and lead), the sum of metabolites of di (2-ethylhexyl) phthalate (DEHP), and MetS, the results remain inconsistent.

- Multiple logistic regression analysis was performed for MetS with log-transformed hazardous material quartiles after covariate adjustment.

- Urine muconic acid (MuA) and mono- (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) levels were significantly associated with MetS after adjusting for confounders (odds ratio: 1.34 and 1.39, respectively).

- This cross-sectional study of a representative sample of adult South Koreans aimed to evaluate the relationship between heavy metals, VOC metabolites, phthalate metabolites, bisphenol A and MetS after adjusting for demographic variables.

- Urine MuA and MEHHP levels were significantly associated with MetS.

- The incidence of metabolic syndrome (MetS), which causes heart disease and stroke, has increased significantly worldwide.


Associated Diseases - DID41130 : Hormone disorders

ZScoreRScoreEntity TypeIDNameSynonyms
2.5792813722 50 - [0, 0, 1, 5] Diseases DID41130 Hormone disorders Hormone disorders; ENDOCRINE PROBLEM; Endocrine Diseases; Endocrine System Diseases; Endocrine disturbance; Hormone disturbance; Disease, Endocrine; Endocrine disorders; endocrine disorder; Diseases, Endocrine; Hormone abnormality; DISORDER ENDOCRINE; Endocrine disease; Endocrinopathy; HORMONAL IMBALANCE

Evidence Section : DID41130 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] An ultrasensitive sensor based on quantitatively modified upconversion particles for trace bisphenol A detection.
[MEDLINE : 30390111]
(2019) An ultrasensitive sensor based on quantitatively modified upconversion particles for trace bisphenol A detection. Analytical and bioanalytical chemistry;Anal Bioanal Chem;2019 Jan;411(1):171-179

- Bisphenol A (BPA) is one of the endocrine-disrupting chemicals which might cause reproductive and endocrine system diseases, and poses a serious threat to the ecosystem and human health.

5 - [0, 0, 0, 1] Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?
[MEDLINE : 30359670]
(2018) Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?. Life sciences;Life Sci.;2018 Dec;214:136-144

- Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes.

5 - [0, 0, 0, 1] Urinary concentration of personal care products and polycystic ovary syndrome: A case-control study.
[MEDLINE : 30265948]
(2019) Urinary concentration of personal care products and polycystic ovary syndrome: A case-control study. Environmental research;Environ. Res.;2019 01;168:48-53

- Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder among females of reproductive age.

5 - [0, 0, 0, 1] Overview of air pollution and endocrine disorders.
[MEDLINE : 29872334]
(2018) Overview of air pollution and endocrine disorders. International journal of general medicine;Int J Gen Med;2018 ;11:191-207

- Overview of air pollution and endocrine disorders.

5 - [0, 0, 0, 1] Triclosan and bisphenol a affect decidualization of human endometrial stromal cells.
[MEDLINE : 26604029]
(2016) Triclosan and bisphenol a affect decidualization of human endometrial stromal cells. Molecular and cellular endocrinology;Mol. Cell. Endocrinol.;2016 Feb;422:74-83

- Among environmental pollutants, endocrine disrupting chemicals (EDCs) act on endocrine system, causing hormonal imbalance which, in turn, leads to female and male reproductive dysfunctions.

5 - [0, 0, 0, 1] Health risk of exposure to Bisphenol A (BPA).
[MEDLINE : 25813067]
(2015) Health risk of exposure to Bisphenol A (BPA). Roczniki Panstwowego Zakladu Higieny;Rocz Panstw Zakl Hig;2015 ;66(1):5-11

- Therefore, BPA has been shown to play a role in the pathogenesis of several endocrine disorders including female and male infertility, precocious puberty, hormone dependent tumours such as breast and prostate cancer and several metabolic disorders including polycystic ovary syndrome (PCOS).


Associated Diseases - DID40143 : Autistic thinking

ZScoreRScoreEntity TypeIDNameSynonyms
2.13143187349 45 - [0, 0, 1, 4] Diseases DID40143 Autistic thinking Autistic thinking; Autism

Evidence Section : DID40143 - MEDLINE

RScore Document Snippets
45 - [0, 0, 1, 4] Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products.
[MEDLINE : 27984170]
(2016) Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products. Neurochemistry international;Neurochem. Int.;2016 Oct;:

- Autism polymorphisms influence the sensitivity to some of these chemicals and these same genes play an important role in barrier function and control of respiratory cilia sweeping particulate matter from the airways.

- Further epidemiological studies and neurodevelopmental and behavioural research is warranted to determine the relevance of large number of suspect candidates whose addition to the environment, household, food and cosmetics might be fuelling the autism epidemic in a gene-dependent manner.

- Gene/environment interactions in autism were analysed using 206 autism susceptibility genes (ASG 's) from the Autworks database to interrogate ∼1 million chemical/gene interactions in the comparative toxicogenomics database.

- Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products.

- The increasing incidence of autism suggests a major environmental influence.


Associated Diseases - DID06945 : LIVER FATTY CHANGE

ZScoreRScoreEntity TypeIDNameSynonyms
1.68358237478 40 - [0, 0, 1, 3] Diseases DID06945 LIVER FATTY CHANGE LIVER FATTY CHANGE; Liver Steatosis; hepatic steatosis; Steatosis of liver; Hepatic lipidosis; STEATOSIS HEPATIC; LIVER FATTY; Liver, Fatty; LIVER FATTY DEGENERATION; Fatty change of liver; Fatty liver disease; Alcoholic fatty liver; Steatosis of liver (disorder)

Evidence Section : DID06945 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?
[MEDLINE : 30359670]
(2018) Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?. Life sciences;Life Sci.;2018 Dec;214:136-144

- Obesity, hepatic steatosis, impaired insulin signaling and pancreatic islet function could be the main results of Bisphenol A exposure.

10 - [0, 0, 0, 2] Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease.
[MEDLINE : 28483554]
(2017) Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease. Biochimica et biophysica acta. Molecular and cell biology of lipids;Biochim Biophys Acta Mol Cell Biol Lipids;2017 Sep;1862(9):869-882

- MiR-192 mimic and lentivirus-mediated overexpression of miR-192 improved BPA-induced hepatic steatosis by suppressing SREBF1.

- Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease.

5 - [0, 0, 0, 1] Xenobiotic-contaminated diets affect hepatic lipid metabolism: Implications for liver steatosis in Sparus aurata juveniles.
[MEDLINE : 26382854]
(2015) Xenobiotic-contaminated diets affect hepatic lipid metabolism: Implications for liver steatosis in Sparus aurata juveniles. Aquatic toxicology (Amsterdam, Netherlands);Aquat. Toxicol.;2015 Oct;167:257-64

- Xenobiotic-contaminated diets affect hepatic lipid metabolism: Implications for liver steatosis in Sparus aurata juveniles.


Associated Diseases - DID49494 : Generalized metabolic disorder

ZScoreRScoreEntity TypeIDNameSynonyms
1.68358237478 40 - [0, 0, 1, 3] Diseases DID49494 Generalized metabolic disorder Generalized metabolic disorder; METABOLIC DISORDERS; Diseases, Metabolic; Metabolic disease; Thesaurismosis; Metabolic disorder; Thesaurismoses; Metabolic Diseases; metabolism disorder; Disease, Metabolic; Disease of metabolism

Evidence Section : DID49494 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] Bisphenol A Exposure May Induce Hepatic Lipid Accumulation via Reprogramming the DNA Methylation Patterns of Genes Involved in Lipid Metabolism.
[MEDLINE : 27502578]
(2016) Bisphenol A Exposure May Induce Hepatic Lipid Accumulation via Reprogramming the DNA Methylation Patterns of Genes Involved in Lipid Metabolism. Scientific reports;Sci Rep;2016 08;6:31331

- Accumulating evidence suggests a role of bisphenol A (BPA) in metabolic disorders.

5 - [0, 0, 0, 1] Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture.
[MEDLINE : 27107150]
(2016) Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture. Aquatic toxicology (Amsterdam, Netherlands);Aquat. Toxicol.;2016 Jun;175:286-98

- Exposure to environmental contaminants has been linked to developmental and reproductive abnormalities leading to infertility, spontaneous abortion, reduced number of offspring, and metabolic disorders.

5 - [0, 0, 0, 1] The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins.
[MEDLINE : 26164745]
(2015) The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins. Environmental toxicology and pharmacology;Environ. Toxicol. Pharmacol.;2015 Jul;40(1):284-91

- The alteration of nutritional intake and fat metabolism may affect the maintenance of pregnancy and supplementation of nutrients to the fetus, and therefore can cause severe metabolic diseases such as ketosis, marasmus and diabetes mellitus in pregnant individuals.

5 - [0, 0, 0, 1] Health risk of exposure to Bisphenol A (BPA).
[MEDLINE : 25813067]
(2015) Health risk of exposure to Bisphenol A (BPA). Roczniki Panstwowego Zakladu Higieny;Rocz Panstw Zakl Hig;2015 ;66(1):5-11

- Therefore, BPA has been shown to play a role in the pathogenesis of several endocrine disorders including female and male infertility, precocious puberty, hormone dependent tumours such as breast and prostate cancer and several metabolic disorders including polycystic ovary syndrome (PCOS).


Associated Diseases - DID06067 : Fibroid

ZScoreRScoreEntity TypeIDNameSynonyms
1.68358237478 40 - [0, 0, 1, 3] Diseases DID06067 Fibroid Fibroid; Fibromyoma; Leiomyomatous Neoplasm; Leiomyoma; Fibromyomas; Leiomyomatous neoplasms; Fibroids; Fibroid Tumors; Fibroid Tumor; fibroid; Leiomyomas; Leiomyomatous Tumor; Leiomyoma nos (morphologic abnormality); Leiomyomatous neoplasm (morphologic abnormality); Leiomyomatous neoplasm nos (morphologic abnormality)

Evidence Section : DID06067 - MEDLINE

RScore Document Snippets
40 - [0, 0, 1, 3] Bisphenol A, benzophenone-type ultraviolet filters, and phthalates in relation to uterine leiomyoma.
[MEDLINE : 25531814]
(2015) Bisphenol A, benzophenone-type ultraviolet filters, and phthalates in relation to uterine leiomyoma. Environmental research;Environ. Res.;2015 Feb;137:101-7

- There was a lack of an association between select nonpersistent chemicals and the odds of a fibroid diagnosis.

- Mono-methyl phthalate levels were significantly lower in women with than without fibroids (1.78µg/g vs. 2.40µg/g).

- Significantly higher geometric mean creatinine-corrected concentrations of BPA, 2,4OH-BP, and 2OH-4MeO-BP were observed in women with than without fibroids [BPA: 2.09µg/g vs. 1.46µg/g p=0.004; 2,4OH-BP:11.10µg/g vs. 6.71µg/g p=0.01; 2OH-4MeO-BP: 11.31µg/g vs. 6.10µg/g p=0.01].

- Urinary concentrations of bisphenol A (BPA), five benzophenone-type UV filters (2-hydroxy-4-methoxybenzophenone (2OH-4MeO-BP), 2,4-dihydroxybenzophenone (2,4OH-BP), 2,2׳-dihydroxybenzophenone (2,2׳OH-4MeO-BP), 2,2׳4,4׳-tetrahydroxybenzophenone (2,2׳4,4׳OH-BP), and 4-hydroxybenzophenone (4OH-BP), and 14 phthalate monoesters were quantified in 495 women who later underwent laparoscopy/laparotomy at 14 clinical sites for the diagnosis of fibroids.


Associated Diseases - DID44631 : infertility

ZScoreRScoreEntity TypeIDNameSynonyms
1.23573287607 35 - [0, 0, 1, 2] Diseases DID44631 infertility infertility; Infertile; Difficulty conceiving

Evidence Section : DID44631 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] Estimation of plasma levels of bisphenol-A &amp; phthalates in fertile &amp; infertile women by gas chromatography-mass spectrometry.
[MEDLINE : 30778008]
(2018) Estimation of plasma levels of bisphenol-A &amp; phthalates in fertile &amp; infertile women by gas chromatography-mass spectrometry. The Indian journal of medical research;Indian J. Med. Res.;2018 Dec;148(6):734-742

- Estimation of plasma levels of bisphenol-A & amp; phthalates in fertile & amp; infertile women by gas chromatography-mass spectrometry.

5 - [0, 0, 0, 1] Melatonin protects prepuberal testis from deleterious effects of bisphenol A or diethylhexyl phthalate by preserving H3K9 methylation.
[MEDLINE : 29655234]
(2018) Melatonin protects prepuberal testis from deleterious effects of bisphenol A or diethylhexyl phthalate by preserving H3K9 methylation. Journal of pineal research;J. Pineal Res.;2018 Sep;65(2):e12497

- The deleterious effects of EDs on spermatogenesis have been well documented, whereas improvement of infertility associated with spermatogenesis defects remains a great challenge.

5 - [0, 0, 0, 1] Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture.
[MEDLINE : 27107150]
(2016) Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture. Aquatic toxicology (Amsterdam, Netherlands);Aquat. Toxicol.;2016 Jun;175:286-98

- Exposure to environmental contaminants has been linked to developmental and reproductive abnormalities leading to infertility, spontaneous abortion, reduced number of offspring, and metabolic disorders.


Associated Diseases - DID69824 : Autism spectrum disorder

ZScoreRScoreEntity TypeIDNameSynonyms
1.23573287607 35 - [0, 0, 1, 2] Diseases DID69824 Autism spectrum disorder Autism spectrum disorder

Evidence Section : DID69824 - MEDLINE

RScore Document Snippets
30 - [0, 0, 1, 1] Sex Differences in the Effects of Prenatal Bisphenol A Exposure on Genes Associated with Autism Spectrum Disorder in the Hippocampus.
[MEDLINE : 30816183]
(2019) Sex Differences in the Effects of Prenatal Bisphenol A Exposure on Genes Associated with Autism Spectrum Disorder in the Hippocampus. Scientific reports;Sci Rep;2019 Feb;9(1):3038

- Sex Differences in the Effects of Prenatal Bisphenol A Exposure on Genes Associated with Autism Spectrum Disorder in the Hippocampus.

- Autism spectrum disorder (ASD) is a neurodevelopmental disorder inexplicably biased towards males.

5 - [0, 0, 0, 1] Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases.
[MEDLINE : 27983596]
(2016) Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases. International journal of molecular sciences;Int J Mol Sci;2016 Dec;17(12):

- Some of these genes are involved with brain diseases, such as Alzheimer 's Disease (AD), Parkinson 's Disease, Huntington 's Disease, Amyotrophic Lateral Sclerosis, Autism Spectrum Disorder, and Brain Neoplasms.


Associated Diseases - DID44658 : Asthma

ZScoreRScoreEntity TypeIDNameSynonyms
1.23573287607 35 - [0, 0, 1, 2] Diseases DID44658 Asthma Asthma

Evidence Section : DID44658 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] Exposure to bisphenol A and the development of asthma: A systematic review of cohort studies.
[MEDLINE : 27542534]
(2016) Exposure to bisphenol A and the development of asthma: A systematic review of cohort studies. Reproductive toxicology (Elmsford, N.Y.);Reprod. Toxicol.;2016 10;65:224-229

- Exposure to bisphenol A and the development of asthma: A systematic review of cohort studies.

5 - [0, 0, 0, 1] Oral Administration of Bisphenol A Directly Exacerbates Allergic Airway Inflammation but Not Allergic Skin Inflammation in Mice.
[MEDLINE : 29846729]
(2018) Oral Administration of Bisphenol A Directly Exacerbates Allergic Airway Inflammation but Not Allergic Skin Inflammation in Mice. Toxicological sciences : an official journal of the Society of Toxicology;Toxicol. Sci.;2018 10;165(2):314-321

- Studies have indicated that BPA possibly exacerbates allergic diseases such as atopic dermatitis and asthma.

5 - [0, 0, 0, 1] The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands.
[MEDLINE : 28703301]
(2018) The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands. Journal of cellular physiology;J. Cell. Physiol.;2018 Mar;233(3):2247-2256

- The identification of specific effects of these endocrine disruptors on ADAM10 and ADAM17 will help to provide a better understanding of their roles in cell signaling and proinflammatory processes, and provide new potential targets for treatment of reproductive or inflammatory diseases such as asthma or breast cancer that are promoted by xenoestrogens.


Associated Diseases - DID47685 : Allergy

ZScoreRScoreEntity TypeIDNameSynonyms
1.23573287607 35 - [0, 0, 1, 2] Diseases DID47685 Allergy Allergy; Hypersensitivity reaction type i disease; Hypersensitivity

Evidence Section : DID47685 - MEDLINE

RScore Document Snippets
25 - [0, 0, 1, 0] Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy.
[MEDLINE : 25445825]
(2015) Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy. The Journal of allergy and clinical immunology;J. Allergy Clin. Immunol.;2015 Feb;135(2):370-8

- Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy.

5 - [0, 0, 0, 1] Role of estrogen receptors α and β in the development of allergic airway inflammation in mice: A possible involvement of interleukin 33 and eosinophils.
[MEDLINE : 30445053]
(2019) Role of estrogen receptors α and β in the development of allergic airway inflammation in mice: A possible involvement of interleukin 33 and eosinophils. Toxicology;Toxicology;2019 01;411:93-100

- Our findings indicate that ERα and ERβ are involved in the proinflammatory response in respiratory allergy, and their effects may be mediated by an increase in the expression of IL-33 and infiltration of eosinophils.

5 - [0, 0, 0, 1] Hypersensitivity to diethylstilbestrol. Cross-sensitization to dienestrol, hexestrol, bisphenol A, p-benzyl-phenol, hydroquinone-monobenzylether, and p-hydroxybenzoic-benzylester.
[MEDLINE : 13701662]
FREGERT,S,S, RORSMAN,H,H (1960) Hypersensitivity to diethylstilbestrol. Cross-sensitization to dienestrol, hexestrol, bisphenol A, p-benzyl-phenol, hydroquinone-monobenzylether, and p-hydroxybenzoic-benzylester. Acta dermato-venereologica;Acta Derm. Venereol.;1960 ;40:206-19

- Hypersensitivity to diethylstilbestrol.


Associated Diseases - DID65672 : -endometriosis

ZScoreRScoreEntity TypeIDNameSynonyms
1.23573287607 35 - [0, 0, 1, 2] Diseases DID65672 -endometriosis -endometriosis; ENDOMETRIOSIS; Endometrioses; Endometrial Growths; Endometrial Implants

Evidence Section : DID65672 - MEDLINE

RScore Document Snippets
35 - [0, 0, 1, 2] Study of possible association between endometriosis and phthalate and bisphenol A by biomarkers analysis.
[MEDLINE : 31063881]
(2019) Study of possible association between endometriosis and phthalate and bisphenol A by biomarkers analysis. Journal of pharmaceutical and biomedical analysis;J Pharm Biomed Anal;2019 Aug;172:238-242

- However, odds ratio (95 % confidence interval - CI) for MiBP, which was found at relatively high concentrations in the samples, by endometriosis was 1.929 (0.507-7.332).

- This paper describes a case-control study to evaluate the relationship between endometriosis and phthalates and BPA exposure, through biomarkers analysis in urine.

- Endocrine disrupting chemicals (EDCs) such as phthalates and bisphenol A (BPA) are substances that may interfere with the actions of endogenous hormones and may be associated with estrogen-related diseases such as endometriosis.


Review Search Parameters

Parameter Name Values
sid

1596377192

timestamp

2020-07-17 16:52:17

query

Bisphenol A

action

association

status

Complete

query type toxin : T3D0637
target types disease : 20
found hits

20

doc count medline : 525
total hits

525

max hits

2000

synonyms bisphenol-a :


This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.