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(2018) Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health. Environmental research;Environ. Res.;2018 02;161:505-511

Bisphenol A and phthalates are widely detected in human urine, blood, breast milk, and amniotic fluid. Both Bisphenol A and phthalates have been suggested as playing a role in obesity epidemics. Exposure to these chemicals during fetal development, and its consequences should be concerning because they can cross the placenta. Thus, this study aimed to assess the association between prenatal exposure to Bisphenol A and phthalates, and cord blood metabolic-related biomarkers. Maternal serum was used during the first trimester, to determine prenatal exposure to Bisphenol A and phthalates. Levels of metabolic-related biomarkers in the cord blood were also determined. Linear regression models were applied to the 365 participants with both, exposure and biomarker assessments, adjusted for maternal age, pre-pregnancy body mass index, parity, education, and sex of the child. The level of Bisphenol A was negatively associated with the leptin level (& # x3b2; = -0.06, 95 % confidence interval [CI]: -0.11, -0.01), but was positively associated with the high-molecular-weight adiponectin level, with marginal significance (& # x3b2; = 0.03, 95 % CI: 0.00, 0.06). The mono-isobutyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), mono- (2-ethylhexyl) phthalate (MEHP), and summation of MEHP and MECPP to represent DEHP exposure (& # x2211; DEHPm) levels were inversely associated with the leptin levels (& # x3b2; =-0.14, 95 % CI: -0.27, -0.01; & # x3b2; = -0.12, 95 % CI: -0.24, 0.00 with marginal significance; & # x3b2; =0.08, 95 % CI: -0.14, -0.03; and & # x3b2; = -0.09, 95 % CI: -0.16, -0.03, respectively). The present study provided some evidence that prenatal exposure to Bisphenol A and certain phthalates may modify fetal adiponectin and leptin levels.

MEDLINE 29223775 : Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health.
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This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.