Diseases : DID70477 - Disease

ZScoreRScoreEntity TypeIDNameSynonyms
4.72059592982 60 - [0, 0, 1, 7] Diseases DID70477 Disease Disease
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25 - [0, 0, 1, 0] Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease.
[MEDLINE : 32796699]
(2020) Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease. International journal of molecular sciences;;2020 Aug;21(16):

- Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease.

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10 - [0, 0, 0, 2] Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A.
[MEDLINE : 27334623]
(2016) Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A. Environmental and molecular mutagenesis;Environ. Mol. Mutagen.;2016 07;57(6):435-46

- This work demonstrated that epigenome-wide discovery experiments in animal models were effective tools for identification and understanding of paralagous epimutations salient to human disease.

- These tumors represent early-onset disease and lack classical sexual dimorphism in incidence.

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5 - [0, 0, 0, 1] Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver.
[MEDLINE : 31683443]
(2020) Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver. Chemosphere;Chemosphere;2020 Feb;241:125092

- Endocrine disruptors (EDs) are important actors in the concept of DOHaD (Developmental Origins of Health and Disease), where epigenetic mechanisms play crucial roles.

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5 - [0, 0, 0, 1] Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism.
[MEDLINE : 28567415]
(2017) Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism. International journal of genomics;Int J Genomics;2017 ;2017:7526592

- The Developmental Origin of Health and Disease (DOHaD) hypothesizes that the environment during fetal and childhood development affects the risk for many chronic diseases in later stages of life, including neurodevelopmental disorders.

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5 - [0, 0, 0, 1] Long Non-Coding RNAs: A Novel Paradigm for Toxicology.
[MEDLINE : 27864543]
(2017) Long Non-Coding RNAs: A Novel Paradigm for Toxicology. Toxicological sciences : an official journal of the Society of Toxicology;Toxicol. Sci.;2017 01;155(1):3-21

- Dysregulation of lncRNAs has been implicated in various human health outcomes such as various cancers, Alzheimer 's disease, cardiovascular disease, autoimmune diseases, as well as intermediary metabolism such as glucose, lipid, and bile acid homeostasis.

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5 - [0, 0, 0, 1] Environmental factors, epigenetics, and developmental origin of reproductive disorders.
[MEDLINE : 27421580]
(2017) Environmental factors, epigenetics, and developmental origin of reproductive disorders. Reproductive toxicology (Elmsford, N.Y.);Reprod. Toxicol.;2017 03;68:85-104

- Human data in support of & quot; Developmental Origins of Health and Disease & quot; (DOHaD) comes from multigenerational studies on offspring of diethylstilbestrol-exposed mothers/grandmothers.

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5 - [0, 0, 0, 1] Lipophilic chemical exposure as a cause of type 2 diabetes (T2D).
[MEDLINE : 23509204]
(2013) Lipophilic chemical exposure as a cause of type 2 diabetes (T2D). Reviews on environmental health;Rev Environ Health;2013 ;28(1):9-20

- This hypothesis suggests that the T2D pandemic as well as the rapid increase of other environmental disease prevalence is, at least in part, due to sequential exposure to levels of lipophilic and hydrophilic environmental pollutants that are much lower than those currently believed to be toxic.

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This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.