| ZScore | RScore | Entity Type | ID | Name | Synonyms |
|---|---|---|---|---|---|
| 6.2975095122 | 95 - [0, 0, 1, 14] | Diseases | DID55595 | malignant tumoral disease | malignant tumoral disease; Malignant neoplastic disease; Cancer morphology; Malignant tumor morphology; malignant tumor; Malignant Neoplasms; neoplasm/cancer; Malignant neoplasm; Malignant tumour; Tumor, malignant; Neoplasms - malignant; CA - Cancer; NEOPLASM MALIGNANT; Cancer; Primary cancer |
| RScore | Document | Snippets | Details |
|---|---|---|---|
| 35 - [0, 0, 1, 2] |
Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17. [MEDLINE : 30065191] |
(2018) Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17. International journal of molecular sciences;Int J Mol Sci;2018 Jul;19(8): - Exposure to BPA or NP is related to cell death, hormonal deregulation, and cancer onset. - These results confirm the capacity of these compounds to induce cell apoptosis in cancer cell lines and uncover ADAM17 as a key regulator of this process in response to EDCs. - Bisphenol-A and Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17. |
Details |
| 10 - [0, 0, 0, 2] |
DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk. [MEDLINE : 27415467] |
(2016) DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk. Epigenetics;Epigenetics;2016 09;11(9):674-689 - Pathway analysis revealed cancer as the top common disease pathway. - Furthermore, clustering analyses using the dataset from The Cancer Genome Atlas revealed that expression of this set of 7 genes was associated with recurrence-free survival of PCa patients. |
Details |
| 5 - [0, 0, 0, 1] |
Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease. [MEDLINE : 32796699] |
(2020) Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease. International journal of molecular sciences;;2020 Aug;21(16): - Several transcription factors, including PPARĪ³, C/EBP, Nrf2, HOX, and HAND2, are involved in BPA action on fat and liver homeostasis, the cardiovascular system, and cancer. |
Details |
| 5 - [0, 0, 0, 1] |
Bisphenol A and polychlorinated biphenyls enhance the cancer stem cell properties of human ovarian cancer cells by activating the WNT signaling pathway. [MEDLINE : 31918092] |
(2020) Bisphenol A and polychlorinated biphenyls enhance the cancer stem cell properties of human ovarian cancer cells by activating the WNT signaling pathway. Chemosphere;Chemosphere;2020 May;246:125775 - Cancer stem cells (CSCs) are a very small subpopulation that have stem-cell qualities, such as exhibiting self-renewal, immortality, and pluripotency, and the capability to differentiate into different tumor cell subtypes. |
Details |
| 5 - [0, 0, 0, 1] |
Chronic Exposure of Mice to Bisphenol-A Alters Uterine Fibroblast Growth Factor Signaling and Leads to Aberrant Epithelial Proliferation. [MEDLINE : 30892605] |
(2019) Chronic Exposure of Mice to Bisphenol-A Alters Uterine Fibroblast Growth Factor Signaling and Leads to Aberrant Epithelial Proliferation. Endocrinology;;2019 05;160(5):1234-1246 - Perturbation of steroid hormone signaling within the uterine milieu could contribute to the development of endometrial hyperplasia and cancer. |
Details |
| 5 - [0, 0, 0, 1] |
Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish. [MEDLINE : 30265984] |
(2018) Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish. Chemosphere;Chemosphere;2018 Dec;213:559-567 - In addition, the results of KOBAS shown in 'Pathways in Cancer ' and 'Cancers ' belong to the top 10 terms in pathway enrichment analyses using genes related to BPF or BPS in human, as was found using GenCLiP. |
Details |
| 5 - [0, 0, 0, 1] |
An integrative transcriptomic analysis reveals bisphenol A exposure-induced dysregulation of microRNA expression in human endometrial cells. [MEDLINE : 28238728] |
(2017) An integrative transcriptomic analysis reveals bisphenol A exposure-induced dysregulation of microRNA expression in human endometrial cells. Toxicology in vitro : an international journal published in association with BIBRA;Toxicol In Vitro;2017 Jun;41:133-142 - Aberrant microRNAs (miRNAs) regulation has been observed in the development of cancer. |
Details |
| 5 - [0, 0, 0, 1] |
Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk. [MEDLINE : 26911702] |
(2016) Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk. Hormones & cancer;Horm Cancer;2016 08;7(4):241-51 - We suggest that dysregulation of inflammatory cytokines, both pro-inflammatory and anti-inflammatory, leads to a microenvironment that may promote disordered cell growth through inhibition of the immune response that targets cancer cells. |
Details |
| 5 - [0, 0, 0, 1] |
Urban Endocrine Disruptors Targeting Breast Cancer Proteins. [MEDLINE : 26700111] |
(2016) Urban Endocrine Disruptors Targeting Breast Cancer Proteins. Chemical research in toxicology;Chem. Res. Toxicol.;2016 Feb;29(2):150-61 - Many of these compounds have been associated with a broad range of diseases including the development or increased susceptibility to breast cancer, the most prevalent cancer in women worldwide, according to the World Health Organization. |
Details |
| 5 - [0, 0, 0, 1] |
Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia. [MEDLINE : 26654562] |
(2016) Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia. Environmental research;Environ. Res.;2016 10;150:573-581 - Oxidative stress arises from excessive free radicals in the body and is a trigger for numerous diseases, such as cancer and atherosclerosis. |
Details |
| 5 - [0, 0, 0, 1] |
Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. [MEDLINE : 25693136] |
(2015) Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. PloS one;PLoS ONE;2015 ;10(2):e0118819 - BPA has become a target of intense public scrutiny following concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer. |
Details |
| 5 - [0, 0, 0, 1] |
The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer. [MEDLINE : 25339261] |
(2015) The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer. Endocrine-related cancer;Endocr. Relat. Cancer;2015 Feb;22(1):R1-31 - The successful use of high-dose synthetic estrogens to treat postmenopausal metastatic breast cancer is the first effective 'chemical therapy ' proven in clinical trial to treat any cancer. |
Details |
Liu Y., Liang Y., Wishart D.S. (2015) PolySearch 2.0: A significantly improved text-mining system for discovering associations between human diseases, genes, drugs, metabolites, toxins, and more. Nucleic Acids Res. 2015 Jul 1;43(Web Server Issue):W535-42.
Cheng D., Knox C., Young N., Stothard P., Damaraju S., Wishart D.S. (2008) PolySearch: a web-based text mining system for extracting relationships between human diseases, genes, mutations, drugs and metabolites. Nucleic Acids Res. 2008 Jul 1;36(Web Server Issue):W399-405.
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.