Diseases : DID34674 - Cardiovascular Diseases

ZScoreRScoreEntity TypeIDNameSynonyms
3.30018401772 60 - [0, 0, 2, 2] Diseases DID34674 Cardiovascular Diseases Cardiovascular Diseases; CVS disease; Cardiovascular Disorder; Disease, Cardiovascular; Diseases, Cardiovascular; Cardiovascular system disease; Cardiovascular Disorders; DISORDER CARDIOVASCULAR; Disease of cardiovascular system; Cardiovascular system diseases; Disease of subdivision of hemolymphoid system
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RScore Document Snippets Details
25 - [0, 0, 1, 0] Cardiogenesis impairment promoted by bisphenol A exposure is successfully counteracted by epigallocatechin gallate.
[MEDLINE : 31126002]
(2019) Cardiogenesis impairment promoted by bisphenol A exposure is successfully counteracted by epigallocatechin gallate. Environmental pollution (Barking, Essex : 1987);;2019 Mar;246:1008-1019

- Exposure to the emerging contaminant bisphenol A (BPA) is ubiquitous and associated with cardiovascular disorders.

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25 - [0, 0, 1, 0] Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes.
[MEDLINE : 31004310]
(2019) Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes. Molecular and cellular biochemistry;Mol. Cell. Biochem.;2019 Aug;458(1-2):171-183

- While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases.

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5 - [0, 0, 0, 1] Genome-wide alteration in DNA hydroxymethylation in the sperm from bisphenol A-exposed men.
[MEDLINE : 28582417]
(2017) Genome-wide alteration in DNA hydroxymethylation in the sperm from bisphenol A-exposed men. PloS one;PLoS ONE;2017 ;12(6):e0178535

- The hyper-hMRs affected genes were enriched in pathways associated with nervous system, development, cardiovascular diseases and signal transduction.

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5 - [0, 0, 0, 1] Maternal bisphenol a exposure impacts the fetal heart transcriptome.
[MEDLINE : 24586524]
(2014) Maternal bisphenol a exposure impacts the fetal heart transcriptome. PloS one;PLoS ONE;2014 ;9(2):e89096

- Our results intensify concerns about the role of BPA in the genesis of human metabolic and cardiovascular diseases.

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This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.