Diseases : DID70477 - Disease

ZScoreRScoreEntity TypeIDNameSynonyms
5.9123438056 90 - [0, 0, 1, 13] Diseases DID70477 Disease Disease
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RScore Document Snippets Details
25 - [0, 0, 1, 0] Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease.
[MEDLINE : 32796699]
(2020) Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease. International journal of molecular sciences;;2020 Aug;21(16):

- Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease.

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10 - [0, 0, 0, 2] Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A.
[MEDLINE : 27334623]
(2016) Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A. Environmental and molecular mutagenesis;Environ. Mol. Mutagen.;2016 07;57(6):435-46

- This work demonstrated that epigenome-wide discovery experiments in animal models were effective tools for identification and understanding of paralagous epimutations salient to human disease.

- These tumors represent early-onset disease and lack classical sexual dimorphism in incidence.

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5 - [0, 0, 0, 1] Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver.
[MEDLINE : 31683443]
(2020) Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver. Chemosphere;Chemosphere;2020 Feb;241:125092

- Endocrine disruptors (EDs) are important actors in the concept of DOHaD (Developmental Origins of Health and Disease), where epigenetic mechanisms play crucial roles.

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5 - [0, 0, 0, 1] Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism.
[MEDLINE : 28567415]
(2017) Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism. International journal of genomics;Int J Genomics;2017 ;2017:7526592

- The Developmental Origin of Health and Disease (DOHaD) hypothesizes that the environment during fetal and childhood development affects the risk for many chronic diseases in later stages of life, including neurodevelopmental disorders.

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5 - [0, 0, 0, 1] Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases.
[MEDLINE : 27983596]
(2016) Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases. International journal of molecular sciences;Int J Mol Sci;2016 Dec;17(12):

- Some of these genes are involved with brain diseases, such as Alzheimer 's Disease (AD), Parkinson 's Disease, Huntington 's Disease, Amyotrophic Lateral Sclerosis, Autism Spectrum Disorder, and Brain Neoplasms.

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5 - [0, 0, 0, 1] Long Non-Coding RNAs: A Novel Paradigm for Toxicology.
[MEDLINE : 27864543]
(2017) Long Non-Coding RNAs: A Novel Paradigm for Toxicology. Toxicological sciences : an official journal of the Society of Toxicology;Toxicol. Sci.;2017 01;155(1):3-21

- Dysregulation of lncRNAs has been implicated in various human health outcomes such as various cancers, Alzheimer 's disease, cardiovascular disease, autoimmune diseases, as well as intermediary metabolism such as glucose, lipid, and bile acid homeostasis.

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5 - [0, 0, 0, 1] Environmental factors, epigenetics, and developmental origin of reproductive disorders.
[MEDLINE : 27421580]
(2017) Environmental factors, epigenetics, and developmental origin of reproductive disorders. Reproductive toxicology (Elmsford, N.Y.);Reprod. Toxicol.;2017 03;68:85-104

- Human data in support of & quot; Developmental Origins of Health and Disease & quot; (DOHaD) comes from multigenerational studies on offspring of diethylstilbestrol-exposed mothers/grandmothers.

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5 - [0, 0, 0, 1] DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk.
[MEDLINE : 27415467]
(2016) DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk. Epigenetics;Epigenetics;2016 09;11(9):674-689

- Pathway analysis revealed cancer as the top common disease pathway.

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5 - [0, 0, 0, 1] Zebrafish embryos as a screen for DNA methylation modifications after compound exposure.
[MEDLINE : 26712470]
(2016) Zebrafish embryos as a screen for DNA methylation modifications after compound exposure. Toxicology and applied pharmacology;Toxicol. Appl. Pharmacol.;2016 Jan;291:84-96

- Modified epigenetic programming early in life is proposed to underlie the development of an adverse adult phenotype, known as the Developmental Origins of Health and Disease (DOHaD) concept.

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5 - [0, 0, 0, 1] CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson's disease mice.
[MEDLINE : 24995576]
(2014) CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson's disease mice. Chemico-biological interactions;Chem. Biol. Interact.;2014 Sep;220:149-57

- Parkinson 's disease (PD) is characterized by the progressive degeneration via apoptosis of nigrostriatal dopaminergic neurons associated with inflammation, resulting in behavioral anomalies.

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5 - [0, 0, 0, 1] Maternal bisphenol a exposure impacts the fetal heart transcriptome.
[MEDLINE : 24586524]
(2014) Maternal bisphenol a exposure impacts the fetal heart transcriptome. PloS one;PLoS ONE;2014 ;9(2):e89096

- Conditions during fetal development influence health and disease in adulthood, especially during critical windows of organogenesis.

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5 - [0, 0, 0, 1] [A memoir of my researches on xenobiotic metabolism for 48 years--researches on Kanemi Yusho and endocrine disrupting chemicals].
[MEDLINE : 23811764]
(2013) [A memoir of my researches on xenobiotic metabolism for 48 years--researches on Kanemi Yusho and endocrine disrupting chemicals]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan;Yakugaku Zasshi;2013 ;133(7):747-72

- In 1968, an epidemic of a & quot; strange disease & quot;, called Yusho, occurred in western Japan.

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5 - [0, 0, 0, 1] Lipophilic chemical exposure as a cause of type 2 diabetes (T2D).
[MEDLINE : 23509204]
(2013) Lipophilic chemical exposure as a cause of type 2 diabetes (T2D). Reviews on environmental health;Rev Environ Health;2013 ;28(1):9-20

- This hypothesis suggests that the T2D pandemic as well as the rapid increase of other environmental disease prevalence is, at least in part, due to sequential exposure to levels of lipophilic and hydrophilic environmental pollutants that are much lower than those currently believed to be toxic.

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This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.