Diseases : DID06945 - LIVER FATTY CHANGE

ZScoreRScoreEntity TypeIDNameSynonyms
5.9123438056 90 - [0, 0, 3, 3] Diseases DID06945 LIVER FATTY CHANGE LIVER FATTY CHANGE; Liver Steatosis; hepatic steatosis; Steatosis of liver; Hepatic lipidosis; STEATOSIS HEPATIC; LIVER FATTY; Liver, Fatty; LIVER FATTY DEGENERATION; Fatty change of liver; Fatty liver disease; Alcoholic fatty liver; Steatosis of liver (disorder)
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50 - [0, 0, 2, 0] Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis.
[MEDLINE : 25748669]
(2015) Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis. Toxicology and applied pharmacology;Toxicol. Appl. Pharmacol.;2015 Apr;284(2):101-12

- Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis.

- Developmental bisphenol A (BPA) exposure increases adulthood hepatic steatosis with reduced mitochondrial function.

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25 - [0, 0, 1, 0] Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?
[MEDLINE : 30359670]
(2018) Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?. Life sciences;Life Sci;2018 Dec;214:136-144

- Obesity, hepatic steatosis, impaired insulin signaling and pancreatic islet function could be the main results of Bisphenol A exposure.

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10 - [0, 0, 0, 2] Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease.
[MEDLINE : 28483554]
(2017) Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease. Biochimica et biophysica acta. Molecular and cell biology of lipids;Biochim Biophys Acta Mol Cell Biol Lipids;2017 Sep;1862(9):869-882

- MiR-192 mimic and lentivirus-mediated overexpression of miR-192 improved BPA-induced hepatic steatosis by suppressing SREBF1.

- Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease.

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5 - [0, 0, 0, 1] Xenobiotic-contaminated diets affect hepatic lipid metabolism: Implications for liver steatosis in Sparus aurata juveniles.
[MEDLINE : 26382854]
(2015) Xenobiotic-contaminated diets affect hepatic lipid metabolism: Implications for liver steatosis in Sparus aurata juveniles. Aquatic toxicology (Amsterdam, Netherlands);Aquat. Toxicol.;2015 Oct;167:257-64

- Xenobiotic-contaminated diets affect hepatic lipid metabolism: Implications for liver steatosis in Sparus aurata juveniles.

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This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.