Diseases : DID38503 - Diabetes mellitus

ZScoreRScoreEntity TypeIDNameSynonyms
11.572023346 155 - [0, 0, 4, 11] Diseases DID38503 Diabetes mellitus Diabetes mellitus; DM - Diabetes mellitus; diabetes; Diabetes mellitus (disorder); Diabetes nos
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55 - [0, 0, 2, 1] Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?
[MEDLINE : 30359670]
(2018) Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?. Life sciences;Life Sci;2018 Dec;214:136-144

- As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adipocyte and skeletal muscles.

- Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes.

- Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

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25 - [0, 0, 1, 0] Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes.
[MEDLINE : 31004310]
(2019) Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes. Molecular and cellular biochemistry;Mol. Cell. Biochem.;2019 Aug;458(1-2):171-183

- Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes.

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25 - [0, 0, 1, 0] Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes. A Pilot Study.
[MEDLINE : 28095285]
(2016) Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes. A Pilot Study. Central European journal of public health;Cent. Eur. J. Public Health;2016 12;24(4):297-301

- Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes.

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15 - [0, 0, 0, 3] Lipophilic chemical exposure as a cause of type 2 diabetes (T2D).
[MEDLINE : 23509204]
(2013) Lipophilic chemical exposure as a cause of type 2 diabetes (T2D). Reviews on environmental health;Rev Environ Health;2013 ;28(1):9-20

- Recent research has shown that diabetes can be caused by exposure to persistent organic pollutants (POPs), exudates from common plastics, air pollution, primary and secondary tobacco smoke, and some pharmaceuticals.

- Lipophilic chemical exposure as a cause of type 2 diabetes (T2D).

- The prevalence of type 2 diabetes (T2D) is increasing worldwide in pandemic-like numbers.

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10 - [0, 0, 0, 2] Urinary concentrations of environmental phenols and their association with type 2 diabetes in a population in Jeddah, Saudi Arabia.
[MEDLINE : 29960220]
(2018) Urinary concentrations of environmental phenols and their association with type 2 diabetes in a population in Jeddah, Saudi Arabia. Environmental research;Environ. Res.;2018 10;166:544-552

- Urinary concentrations of environmental phenols and their association with type 2 diabetes in a population in Jeddah, Saudi Arabia.

- Unconditional logistic regression was performed to estimate odd ratios (ORs) for the association between diabetes and EDC exposures after adjusting for confounders including age, gender, nationality, smoking status and occupation.

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5 - [0, 0, 0, 1] Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice.
[MEDLINE : 28962342]
(2015) Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice. Toxicology reports;Toxicol Rep;2015 ;2:99-110

- Previous observations that BPA exposure increased the prevalence of diabetes and insulitis and decreased the number of tissue resident macrophages in pancreas were confirmed, and extended by demonstrating that BPA exposure also impaired the phagocytic activity of peritoneal macrophages.

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5 - [0, 0, 0, 1] Low-dose pollutant mixture triggers metabolic disturbances in female mice leading to common and specific features as compared to a high-fat diet.
[MEDLINE : 28433925]
(2017) Low-dose pollutant mixture triggers metabolic disturbances in female mice leading to common and specific features as compared to a high-fat diet. The Journal of nutritional biochemistry;J. Nutr. Biochem.;2017 07;45:83-93

- Environmental pollutants are potential etiologic factors of obesity and diabetes that reach epidemic proportions worldwide.

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5 - [0, 0, 0, 1] The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins.
[MEDLINE : 26164745]
(2015) The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins. Environmental toxicology and pharmacology;Environ. Toxicol. Pharmacol.;2015 Jul;40(1):284-91

- The alteration of nutritional intake and fat metabolism may affect the maintenance of pregnancy and supplementation of nutrients to the fetus, and therefore can cause severe metabolic diseases such as ketosis, marasmus and diabetes mellitus in pregnant individuals.

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5 - [0, 0, 0, 1] Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts.
[MEDLINE : 25693136]
(2015) Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. PloS one;PLoS ONE;2015 ;10(2):e0118819

- BPA has become a target of intense public scrutiny following concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer.

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5 - [0, 0, 0, 1] Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice.
[MEDLINE : 24959901]
(2014) Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice. PloS one;PLoS ONE;2014 ;9(6):e100214

- This term refers to a form of diabetes which typically develops in later life and is associated with obesity.

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This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.