Diseases : DID44658 - Asthma

ZScoreRScoreEntity TypeIDNameSynonyms
1.12338419449 35 - [0, 0, 1, 2] Diseases DID44658 Asthma Asthma
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RScore Document Snippets Details
25 - [0, 0, 1, 0] Exposure to bisphenol A and the development of asthma: A systematic review of cohort studies.
[MEDLINE : 27542534]
(2016) Exposure to bisphenol A and the development of asthma: A systematic review of cohort studies. Reproductive toxicology (Elmsford, N.Y.);Reprod. Toxicol.;2016 10;65:224-229

- Exposure to bisphenol A and the development of asthma: A systematic review of cohort studies.

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5 - [0, 0, 0, 1] Oral Administration of Bisphenol A Directly Exacerbates Allergic Airway Inflammation but Not Allergic Skin Inflammation in Mice.
[MEDLINE : 29846729]
(2018) Oral Administration of Bisphenol A Directly Exacerbates Allergic Airway Inflammation but Not Allergic Skin Inflammation in Mice. Toxicological sciences : an official journal of the Society of Toxicology;Toxicol. Sci.;2018 10;165(2):314-321

- Studies have indicated that BPA possibly exacerbates allergic diseases such as atopic dermatitis and asthma.

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5 - [0, 0, 0, 1] The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands.
[MEDLINE : 28703301]
(2018) The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands. Journal of cellular physiology;J. Cell. Physiol.;2018 Mar;233(3):2247-2256

- The identification of specific effects of these endocrine disruptors on ADAM10 and ADAM17 will help to provide a better understanding of their roles in cell signaling and proinflammatory processes, and provide new potential targets for treatment of reproductive or inflammatory diseases such as asthma or breast cancer that are promoted by xenoestrogens.

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This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.