Diseases : DID49494 - Generalized metabolic disorder

ZScoreRScoreEntity TypeIDNameSynonyms
1.60163263284 40 - [0, 0, 1, 3] Diseases DID49494 Generalized metabolic disorder Generalized metabolic disorder; METABOLIC DISORDERS; Diseases, Metabolic; Metabolic disease; Thesaurismosis; Metabolic disorder; Thesaurismoses; Metabolic Diseases; metabolism disorder; Disease, Metabolic; Disease of metabolism
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RScore Document Snippets Details
25 - [0, 0, 1, 0] Bisphenol A Exposure May Induce Hepatic Lipid Accumulation via Reprogramming the DNA Methylation Patterns of Genes Involved in Lipid Metabolism.
[MEDLINE : 27502578]
(2016) Bisphenol A Exposure May Induce Hepatic Lipid Accumulation via Reprogramming the DNA Methylation Patterns of Genes Involved in Lipid Metabolism. Scientific reports;Sci Rep;2016 08;6:31331

- Accumulating evidence suggests a role of bisphenol A (BPA) in metabolic disorders.

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5 - [0, 0, 0, 1] Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture.
[MEDLINE : 27107150]
(2016) Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture. Aquatic toxicology (Amsterdam, Netherlands);Aquat. Toxicol.;2016 Jun;175:286-98

- Exposure to environmental contaminants has been linked to developmental and reproductive abnormalities leading to infertility, spontaneous abortion, reduced number of offspring, and metabolic disorders.

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5 - [0, 0, 0, 1] The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins.
[MEDLINE : 26164745]
(2015) The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins. Environmental toxicology and pharmacology;Environ. Toxicol. Pharmacol.;2015 Jul;40(1):284-91

- The alteration of nutritional intake and fat metabolism may affect the maintenance of pregnancy and supplementation of nutrients to the fetus, and therefore can cause severe metabolic diseases such as ketosis, marasmus and diabetes mellitus in pregnant individuals.

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5 - [0, 0, 0, 1] Health risk of exposure to Bisphenol A (BPA).
[MEDLINE : 25813067]
(2015) Health risk of exposure to Bisphenol A (BPA). Roczniki Panstwowego Zakladu Higieny;Rocz Panstw Zakl Hig;2015 ;66(1):5-11

- Therefore, BPA has been shown to play a role in the pathogenesis of several endocrine disorders including female and male infertility, precocious puberty, hormone dependent tumours such as breast and prostate cancer and several metabolic disorders including polycystic ovary syndrome (PCOS).

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This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.