Diseases : DID71361 - Obesity

ZScoreRScoreEntity TypeIDNameSynonyms
13.8943663428 180 - [0, 1, 3, 11] Diseases DID71361 Obesity Obesity
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RScore Document Snippets Details
55 - [0, 1, 0, 1] Obesity aggravates toxic effect of BPA on spermatogenesis.
[MEDLINE : 28501790]
(2017) Obesity aggravates toxic effect of BPA on spermatogenesis. Environment international;Environ Int;2017 08;105:56-65

- Obesity aggravates toxic effect of BPA on spermatogenesis.

- Both bisphenol A (BPA) and obesity affect male reproductive system.

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25 - [0, 0, 1, 0] Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?
[MEDLINE : 30359670]
(2018) Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?. Life sciences;Life Sci.;2018 Dec;214:136-144

- Obesity, hepatic steatosis, impaired insulin signaling and pancreatic islet function could be the main results of Bisphenol A exposure.

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25 - [0, 0, 1, 0] Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health.
[MEDLINE : 29223775]
(2018) Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health. Environmental research;Environ. Res.;2018 02;161:505-511

- Both bisphenol A and phthalates have been suggested as playing a role in obesity epidemics.

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25 - [0, 0, 1, 0] Urinary bisphenol A is associated with insulin resistance and obesity in reproductive-aged women.
[MEDLINE : 27801986]
(2017) Urinary bisphenol A is associated with insulin resistance and obesity in reproductive-aged women. Clinical endocrinology;Clin. Endocrinol. (Oxf);2017 Apr;86(4):506-512

- Urinary bisphenol A is associated with insulin resistance and obesity in reproductive-aged women.

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10 - [0, 0, 0, 2] Low-dose pollutant mixture triggers metabolic disturbances in female mice leading to common and specific features as compared to a high-fat diet.
[MEDLINE : 28433925]
(2017) Low-dose pollutant mixture triggers metabolic disturbances in female mice leading to common and specific features as compared to a high-fat diet. The Journal of nutritional biochemistry;J. Nutr. Biochem.;2017 07;45:83-93

- However, it is important to determine if pollutants could exert metabolic defects without directly inducing obesity.

- Environmental pollutants are potential etiologic factors of obesity and diabetes that reach epidemic proportions worldwide.

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5 - [0, 0, 0, 1] Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver.
[MEDLINE : 31683443]
(2020) Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver. Chemosphere;Chemosphere;2020 Feb;241:125092

- Environmental pollution is increasingly considered an important factor involved in the obesity incidence.

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5 - [0, 0, 0, 1] Short and long-term effects of bisphenol S (BPS) exposure during pregnancy and lactation on plasma lipids, hormones, and behavior in rats.
[MEDLINE : 31003143]
(2019) Short and long-term effects of bisphenol S (BPS) exposure during pregnancy and lactation on plasma lipids, hormones, and behavior in rats. Environmental pollution (Barking, Essex : 1987);Environ. Pollut.;2019 Jul;250:312-322

- Furthermore, the increased preference for the fat-enriched diet suggests an increased risk for obesity and its health consequences in the long term.

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5 - [0, 0, 0, 1] Effects of diethylene glycol dibenzoate and Bisphenol A on the lipid metabolism of Danio rerio.
[MEDLINE : 29723837]
(2018) Effects of diethylene glycol dibenzoate and Bisphenol A on the lipid metabolism of Danio rerio. The Science of the total environment;Sci. Total Environ.;2018 Sep;636:641-655

- Endocrine disrupting chemicals (EDCs) are known to disrupt normal metabolism and can influence the incidence of obesity in animals and humans.

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5 - [0, 0, 0, 1] Obesogen effects after perinatal exposure of 4,4'-sulfonyldiphenol (Bisphenol S) in C57BL/6 mice.
[MEDLINE : 27241191]
(2016) Obesogen effects after perinatal exposure of 4,4'-sulfonyldiphenol (Bisphenol S) in C57BL/6 mice. Toxicology;Toxicology;2016 05;357-358:11-20

- BPS potentiated the obesity induced by a HFD by inducing the lipid storage linked to faster lipid plasma clearance.

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5 - [0, 0, 0, 1] Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A.
[MEDLINE : 26521216]
(2015) Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A. Environment international;Environ Int;2015 Dec;85:352-79

- Up to date findings indicated the association of ClxBPA with metabolic conditions, such as obesity, lipid accumulation, and type 2 diabetes mellitus, particularly in in-vitro and in-vivo studies.

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5 - [0, 0, 0, 1] Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts.
[MEDLINE : 25693136]
(2015) Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. PloS one;PLoS ONE;2015 ;10(2):e0118819

- BPA has become a target of intense public scrutiny following concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer.

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5 - [0, 0, 0, 1] Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice.
[MEDLINE : 24959901]
(2014) Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice. PloS one;PLoS ONE;2014 ;9(6):e100214

- This term refers to a form of diabetes which typically develops in later life and is associated with obesity.

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5 - [0, 0, 0, 1] Toxicogenomics in the 3T3-L1 cell line, a new approach for screening of obesogenic compounds.
[MEDLINE : 24848799]
(2014) Toxicogenomics in the 3T3-L1 cell line, a new approach for screening of obesogenic compounds. Toxicological sciences : an official journal of the Society of Toxicology;Toxicol. Sci.;2014 Aug;140(2):352-63

- The obesogen hypothesis states that together with an energy imbalance between calories consumed and calories expended, exposure to environmental compounds early in life or throughout lifetime might have an influence on obesity development.

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This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.