Diseases : DID06582 - breast neoplasm

ZScoreRScoreEntity TypeIDNameSynonyms
16.0894973624 205 - [0, 0, 4, 21] Diseases DID06582 breast neoplasm breast neoplasm; Breast tumour; Neoplasm of breast; Breast Neoplasm; Tumors, Breast; Breast Tumor; Tumor of the Breast; Tumor, Breast; mammary tumor; Breast Neoplasms; Tumor of breast; Tumour of breast; Neoplasm of the Breast; Mammary Neoplasms; Breast Tumors; NEOPLASM BREAST; Neoplasm, Breast; Breast cancer; Breast cancer; Ca breast - nos; Malignant neoplasm of breast; Malignant tumor of the breast; Mammary cancer; Primary breast cancer
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45 - [0, 0, 1, 4] Urban Endocrine Disruptors Targeting Breast Cancer Proteins.
[MEDLINE : 26700111]
(2016) Urban Endocrine Disruptors Targeting Breast Cancer Proteins. Chemical research in toxicology;Chem. Res. Toxicol.;2016 Feb;29(2):150-61

- Many of these compounds have been associated with a broad range of diseases including the development or increased susceptibility to breast cancer, the most prevalent cancer in women worldwide, according to the World Health Organization.

- Thus, this article presents a virtual high-throughput screening (vHTS) to evaluate the affinity of proteins related to breast cancer, such as ESR1, ERBB2, PGR, BCRA1, and SHBG, among others, with EDCs from urban sources.

- Urban Endocrine Disruptors Targeting Breast Cancer Proteins.

- In short, this work shows the potential of several EDCs to bind breast cancer associated proteins as a tool to prioritize compounds to perform in vitro analysis to benefit the regulation or exposure prevention by the general population.

- Some of the chemicals that exhibited the best affinity scores for breast cancer proteins in each category were 1,3,7,8-tetrachlorodibenzo-p-dioxin, bisphenol A derivatives, perfluorooctanesulfonic acid, and benzo (a) pyrene, for catalase, several proteins, sex hormone-binding globulin, and cytochrome P450 1A2, respectively.

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30 - [0, 0, 1, 1] Repeated Exposure to 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), an Active Metabolite of Bisphenol A, Aggressively Stimulates Breast Cancer Cell Growth in an Estrogen Receptor <i>β</i> (ER<i>β</i>)-Dependent Manner.
[MEDLINE : 30552153]
(2019) Repeated Exposure to 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), an Active Metabolite of Bisphenol A, Aggressively Stimulates Breast Cancer Cell Growth in an Estrogen Receptor <i>β</i> (ER<i>β</i>)-Dependent Manner. Molecular pharmacology;Mol. Pharmacol.;2019 Mar;95(3):260-268

- We have focused on the biologic relationship between breast tumor promotion and MBP/BPA, because BPA is considered to be a human carcinogen owing to its breast tumor-promoting properties.

- Repeated Exposure to 4-Methyl-2,4-bis (4-hydroxyphenyl) pent-1-ene (MBP), an Active Metabolite of Bisphenol A, Aggressively Stimulates Breast Cancer Cell Growth in an Estrogen Receptor < i > β < /i > (ER < i > β < /i >) -Dependent Manner.

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30 - [0, 0, 1, 1] Editor's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells.
[MEDLINE : 28591870]
(2017) Editor's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells. Toxicological sciences : an official journal of the Society of Toxicology;Toxicol. Sci.;2017 08;158(2):431-443

- These findings point to the importance of better understanding the risk of adverse effects from exposure to BPA alternatives, including hormone-dependent breast cancer.

- Editor 's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells.

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25 - [0, 0, 0, 5] Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7.
[MEDLINE : 30616060]
(2019) Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7. Environmental pollution (Barking, Essex : 1987);Environ. Pollut.;2019 Mar;246:697-703

- Gene expression profiling showed that some genes related to breast cancer progression were upregulated, including THBS4, PPARGC1A, CREB5, COL5A3.

- Gene ontology (GO) analysis of the differentially expressed genes revealed the significantly changes in PI3K-Akt signaling pathway and extracellular matrix, which were related to the proliferation, migration and invasion of breast cancer cells.

- Besides, methylation status in promoter of breast cancer related genes CDH1, SFN, TNFRSF10C were also changed, which implied that BPS might play a role in the development of breast cancer.

- These results illustrated that BPS exposure might play roles in the progression of breast cancer.

- Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7.

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25 - [0, 0, 1, 0] DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients.
[MEDLINE : 28505145]
(2017) DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients. Genes;Genes (Basel);2017 May;8(5):

- DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients.

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15 - [0, 0, 0, 3] The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer.
[MEDLINE : 25339261]
(2015) The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer. Endocrine-related cancer;Endocr. Relat. Cancer;2015 Feb;22(1):R1-31

- This review documents the clinical use of estrogen for breast cancer treatment or estrogen replacement therapy (ERT) in postmenopausal hysterectomized women, which can either result in breast cancer cell growth or breast cancer regression.

- The symmetry of the clinical and laboratory studies now permits the creation of rules for the future clinical application of ERT or phytoestrogen supplements: a 5-year gap is necessary after menopause to permit the selection of estrogen-deprived breast cancer cell populations to cause them to become vulnerable to apoptotic cell death.

- The key to triggering apoptosis with estrogen is the selection of breast cancer cell populations that are resistant to long-term estrogen deprivation.

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5 - [0, 0, 0, 1] Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish.
[MEDLINE : 30265984]
(2018) Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish. Chemosphere;Chemosphere;2018 Dec;213:559-567

- Moreover, the Kaplan-Meier survival analysis was performed using homologenes (MST1R, PIK3CB and PRKCD) of hub genes in human to evaluate whether exposure to bisphenols may adversely affect breast cancer.

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5 - [0, 0, 0, 1] Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine‑disrupting chemicals.
[MEDLINE : 30226539]
(2018) Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine‑disrupting chemicals. Oncology reports;Oncol. Rep.;2018 Nov;40(5):2766-2777

- Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine‑disrupting chemicals.

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5 - [0, 0, 0, 1] Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression.
[MEDLINE : 29783106]
(2018) Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression. Ecotoxicology and environmental safety;Ecotoxicol. Environ. Saf.;2018 Sep;160:1-9

- Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression.

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5 - [0, 0, 0, 1] Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells.
[MEDLINE : 29093337]
(2017) Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells. Biological &amp; pharmaceutical bulletin;Biol. Pharm. Bull.;2017 ;40(11):1909-1916

- Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells.

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5 - [0, 0, 0, 1] The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands.
[MEDLINE : 28703301]
(2018) The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands. Journal of cellular physiology;J. Cell. Physiol.;2018 Mar;233(3):2247-2256

- The identification of specific effects of these endocrine disruptors on ADAM10 and ADAM17 will help to provide a better understanding of their roles in cell signaling and proinflammatory processes, and provide new potential targets for treatment of reproductive or inflammatory diseases such as asthma or breast cancer that are promoted by xenoestrogens.

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5 - [0, 0, 0, 1] Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk.
[MEDLINE : 26911702]
(2016) Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk. Hormones &amp; cancer;Horm Cancer;2016 08;7(4):241-51

- The recent rise in incidence of human breast cancer and decreased age of first detection suggests a possible environmental etiology.

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5 - [0, 0, 0, 1] Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors.
[MEDLINE : 26704594]
(2016) Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors. Journal of medicinal chemistry;J. Med. Chem.;2016 Jan;59(1):157-70

- The hypothesis is that in normal tissue the estrogenic SERM activity of a dual AI/SERM could attenuate the undesired effects stemming from global estrogen depletion caused by the AI activity of a dual AI/SERM, while in breast cancer tissue the antiestrogenic SERM activity of a dual AI/SERM could act synergistically with AI activity to enhance the antiproliferative effect.

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This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.