Diseases : DID55595 - malignant tumoral disease

ZScoreRScoreEntity TypeIDNameSynonyms
5.26637836446 80 - [0, 0, 1, 11] Diseases DID55595 malignant tumoral disease malignant tumoral disease; Malignant neoplastic disease; Cancer morphology; Malignant tumor morphology; malignant tumor; Malignant Neoplasms; neoplasm/cancer; Malignant neoplasm; Malignant tumour; Tumor, malignant; Neoplasms - malignant; CA - Cancer; NEOPLASM MALIGNANT; Cancer; Primary cancer
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RScore Document Snippets Details
35 - [0, 0, 1, 2] Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17.
[MEDLINE : 30065191]
(2018) Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17. International journal of molecular sciences;Int J Mol Sci;2018 Jul;19(8):

- Exposure to BPA or NP is related to cell death, hormonal deregulation, and cancer onset.

- These results confirm the capacity of these compounds to induce cell apoptosis in cancer cell lines and uncover ADAM17 as a key regulator of this process in response to EDCs.

- Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17.

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10 - [0, 0, 0, 2] DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk.
[MEDLINE : 27415467]
(2016) DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk. Epigenetics;Epigenetics;2016 09;11(9):674-689

- Pathway analysis revealed cancer as the top common disease pathway.

- Furthermore, clustering analyses using the dataset from The Cancer Genome Atlas revealed that expression of this set of 7 genes was associated with recurrence-free survival of PCa patients.

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5 - [0, 0, 0, 1] Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish.
[MEDLINE : 30265984]
(2018) Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish. Chemosphere;Chemosphere;2018 Dec;213:559-567

- In addition, the results of KOBAS shown in 'Pathways in Cancer ' and 'Cancers ' belong to the top 10 terms in pathway enrichment analyses using genes related to BPF or BPS in human, as was found using GenCLiP.

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5 - [0, 0, 0, 1] An integrative transcriptomic analysis reveals bisphenol A exposure-induced dysregulation of microRNA expression in human endometrial cells.
[MEDLINE : 28238728]
(2017) An integrative transcriptomic analysis reveals bisphenol A exposure-induced dysregulation of microRNA expression in human endometrial cells. Toxicology in vitro : an international journal published in association with BIBRA;Toxicol In Vitro;2017 Jun;41:133-142

- Aberrant microRNAs (miRNAs) regulation has been observed in the development of cancer.

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5 - [0, 0, 0, 1] Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk.
[MEDLINE : 26911702]
(2016) Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk. Hormones & cancer;Horm Cancer;2016 08;7(4):241-51

- We suggest that dysregulation of inflammatory cytokines, both pro-inflammatory and anti-inflammatory, leads to a microenvironment that may promote disordered cell growth through inhibition of the immune response that targets cancer cells.

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5 - [0, 0, 0, 1] Urban Endocrine Disruptors Targeting Breast Cancer Proteins.
[MEDLINE : 26700111]
(2016) Urban Endocrine Disruptors Targeting Breast Cancer Proteins. Chemical research in toxicology;Chem. Res. Toxicol.;2016 Feb;29(2):150-61

- Many of these compounds have been associated with a broad range of diseases including the development or increased susceptibility to breast cancer, the most prevalent cancer in women worldwide, according to the World Health Organization.

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5 - [0, 0, 0, 1] Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia.
[MEDLINE : 26654562]
(2016) Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia. Environmental research;Environ. Res.;2016 10;150:573-581

- Oxidative stress arises from excessive free radicals in the body and is a trigger for numerous diseases, such as cancer and atherosclerosis.

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5 - [0, 0, 0, 1] Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts.
[MEDLINE : 25693136]
(2015) Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. PloS one;PLoS ONE;2015 ;10(2):e0118819

- BPA has become a target of intense public scrutiny following concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer.

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5 - [0, 0, 0, 1] The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer.
[MEDLINE : 25339261]
(2015) The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer. Endocrine-related cancer;Endocr. Relat. Cancer;2015 Feb;22(1):R1-31

- The successful use of high-dose synthetic estrogens to treat postmenopausal metastatic breast cancer is the first effective 'chemical therapy ' proven in clinical trial to treat any cancer.

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This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.