PolySearch 2.0 significantly expanded custom thesauri from 9 to 20 categories, and from just 3000 to over 1.13 million term entries. In particular we have expanded the thesauri to include toxins, food metabolites, biological taxonomies, pathways, as well as Gene Ontology, MeSH terms, and ICD-10 codes. The thesauri also feature many manually curated terms and synonyms for health effects, drug effects, adverse effects, and chemical taxonomies. The table below summarizes the number of term entries and synonyms for each thesaurus
| Thesaurus Name | Number of Terms | Number of Synonyms |
|---|---|---|
| Gene Families | 404 | 948 |
| Adverse Health Effects | 135 | 711 |
| Health Effects | 161 | 507 |
| Gene Ontology | 40535 | 110477 |
| Toxins | 3713 | 39095 |
| Biological Taxonomy | 607031 | 775728 |
| Drugs | 7670 | 37331 |
| ICD-10 Codes | 91737 | 155331 |
| Chemical Ontology | 4017 | 10098 |
| Tissues | 954 | 984 |
| MeSH Terms | 26956 | 215327 |
| Food Metabolites | 27509 | 39278 |
| Genes and Proteins | 27994 | 287827 |
| Drug Effects | 424 | 590 |
| Metabolic Pathways | 456 | 456 |
| MeSH Compounds | 221986 | 716676 |
| Human Metabolites | 41793 | 381195 |
| Organs | 104 | 201 |
| Subcellular Locations | 74 | 175 |
| Diseases | 27658 | 76001 |
| Total | 1131328 | 2848936 |
PolySearch 2.0 significantly expanded number of text corpora and databases (by >80%) to include a total of 6 free-text corpora and 14 bioinformatics databases. The latest server searches against over 43 million articles covering Medline abstracts, PubMed Central full-text, Wikipedia articles, US Patent abstracts, and open access textbooks.
| Total Number of indexed Records in OMIM | 23219 |
| Total Number of indexed Records in T3DB | 3713 |
| Total Number of indexed Records in HMDB | 41513 |
| Total Number of indexed Documents in MEDLINE | 27208664 |
| Total Number of indexed Documents in Wikipedia | 7619689 |
| Total Number of indexed Documents in USPTO | 7996999 |
| Total Number of indexed Records in FooDB | 27509 |
| Total Number of indexed Records in KEGG Reactions | 9538 |
| Total Number of indexed Records in Gene Ontology | 40535 |
| Total Number of indexed Records in DailyMed | 2745 |
| Total Number of indexed Records in KEGG Pathways | 456 |
| Total Number of indexed Documents in NCBI Books | 19066 |
| Total Number of indexed Documents in MedlinePlus | 1901 |
| Total Number of indexed Documents in PubMed Central | 704539 |
| Total Number of indexed Records in SwissProt | 541561 |
| Total Number of indexed Records in MetaCyc | 3810 |
| Total Number of indexed Records in GAD | 167298 |
| Total Number of indexed Records in HPRD | 18863 |
| Total Number of indexed Records in DrugBank | 6825 |
Liu Y., Liang Y., Wishart D.S. (2015) PolySearch 2.0: A significantly improved text-mining system for discovering associations between human diseases, genes, drugs, metabolites, toxins, and more. Nucleic Acids Res. 2015 Jul 1;43(Web Server Issue):W535-42.
Cheng D., Knox C., Young N., Stothard P., Damaraju S., Wishart D.S. (2008) PolySearch: a web-based text mining system for extracting relationships between human diseases, genes, mutations, drugs and metabolites. Nucleic Acids Res. 2008 Jul 1;36(Web Server Issue):W399-405.
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government.